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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Prevalence of neutralizing antibody to respiratory syncytial virus in sera from mothers and newborns residing in the Gambia and in The United States.
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Prevalence of neutralizing antibody to respiratory syncytial virus in sera from mothers and newborns residing in the Gambia and in The United States.

机译：来自冈比亚和美国的母亲和新生儿血清中呼吸道合胞病毒的中和抗体的流行率。

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摘要

The prevalence of maternal respiratory syncytial virus (RSV)-neutralizing antibodies has been documented in developed countries, but there is little information from developing countries. We assessed the prevalence of RSV-neutralizing antibody in sera from Gambian women and their newborns and compared them with their American counterparts during a similar period. The geometric mean titers of maternal antibodies to RSV subgroup A in the two populations were similar, while titers of antibodies to RSV subgroup B in Gambian mothers were significantly higher (8.7 +/- 1.4 versus 7.9 +/- 1.3 [mean +/- standard deviation], P < 0.001). The titers of neutralizing antibody in newborns in both populations correlated with the neutralizing-antibody titers of their mothers. Thus, the status of neutralizing antibody to both major RSV subgroups was comparable among infants and mothers in a developing country, The Gambia, and those in a developed country, the United States.
机译：发达国家已有母体呼吸道合胞病毒（RSV）中和抗体的流行记录，但发展中国家的信息很少。我们评估了冈比亚妇女及其新生儿血清中RSV中和抗体的患病率，并将其与美国同期的血清进行了比较。在这两个人群中，针对RSV亚组的母体抗体的几何平均滴度相似，而冈比亚母亲针对RSV亚组的抗体的滴度明显更高（8.7 +/- 1.4对7.9 +/- 1.3 [平均值+/-标准偏差]，P <0.001）。两种人群中新生儿的中和抗体滴度与其母亲的中和抗体滴度相关。因此，在发展中国家冈比亚的婴儿和母亲与发达国家的婴儿的母亲中，针对两个主要RSV亚群的中和抗体的状况是可比的。

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