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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Immunoblot analysis of anti-Ureaplasma urealyticum antibody in pregnant women and newborn infants.
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Immunoblot analysis of anti-Ureaplasma urealyticum antibody in pregnant women and newborn infants.

机译：孕妇和新生婴儿抗解脲脲原体抗体的免疫印迹分析。

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The purpose of the present study was to determine the frequency in which antibody reactive to Ureaplasma urealyticum could be detected in a population of pregnant women and newborn infants. Serum samples from a prospective cohort of 80 healthy, U. urealyticum culture-positive and culture-negative pregnant women and a retrospective cohort of 522 infants born at between 25 and 42 weeks of gestation were studied by immunoblot analysis. Cultures of specimens from the lower genital tract were positive for U. urealyticum for 83% of the pregnant women, and serum immunoglobulin G (IgG) antibody which reacted to U. urealyticum was detectable in 93% of the pregnant women. Samples from five women (8%) had increases in the number of anti-U. urealyticum IgG bands over the course of the pregnancy. Samples from four of these five women had corresponding increases in the number of antibody bands present in IgA immunoblots. Six of the 522 samples from newborns or cord blood (1.1%) were positive for anti-U. urealyticum IgA; 5 of these 6 samples were also positive for IgM. The six anti-U. urealyticum IgA-positive infants were distributed as follows; 3 of 67 (4.5%) infants were delivered at 25 to 30 weeks of gestation, 3 of 176 (1.7%) infants were delivered at 31 to 34 weeks of gestation, and 0 of 279 infants were delivered at > or = 35 weeks of gestation. An antibody response to U. urealyticum can be detected in pregnant women and preterm infants and may serve as a marker of infection.
机译：本研究的目的是确定在孕妇和新生儿中可以检测到对解脲支原体具有反应性的抗体的频率。通过免疫印迹分析研究了来自80位健康的解脲脲原体培养阳性和培养阴性孕妇的前瞻性队列以及522名出生在妊娠25至42周之间的婴儿的回顾性队列。下生殖道标本的培养对于83％的孕妇呈解脲脲原体阳性，在93％的孕妇中可检测到与解脲脲原体反应的血清免疫球蛋白G（IgG）抗体。五名妇女（8％）的样本中抗-U的数量增加。在妊娠过程中出现解脲脲原体IgG条带。这五位女性中有四位的样本在IgA免疫印迹中存在的抗体条带数量相应增加。新生儿或脐带血的522个样本中有六个（1.1％）呈抗U阳性。解脲脲IgA;这6个样本中有5个也呈阳性。六防U。解脲脲原体IgA阳性婴儿的分布如下： 67个婴儿中的3个（4.5％）在妊娠25至30周分娩，176个婴儿中的3个（1.7％）在妊娠31至34周分娩，279个婴儿中的0个在≥35周分娩妊娠。可以在孕妇和早产儿中检测到对解脲支原体的抗体反应，并且可以作为感染的标志。

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