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首页> 外文期刊>Clinical and diagnostic laboratory immunology >Elevated concentrations of interleukin-1 beta and interleukin-1 receptor antagonist in plasma of women with silicone breast implants.
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Elevated concentrations of interleukin-1 beta and interleukin-1 receptor antagonist in plasma of women with silicone breast implants.

机译：带有硅胶乳房植入物的女性血浆中白介素-1β和白介素-1受体拮抗剂的浓度升高。

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Plasma from 27 women with silicone breast implants (SBIs) and 50 age-matched control women without SBIs were examined by enzyme immunoassay for the presence of interleukin-1 beta (IL-1 beta) and its naturally occurring receptor antagonist, IL-1ra. The results show that 74% (20 of 27) of women with SBIs had elevated concentrations of IL-1ra, whereas only 2% (1 of 50) of controls without SBIs had elevated concentrations of IL-1ra. In contrast to the IL-1ra results, the frequency of elevated IL-1 beta concentrations among women with SBIs was only 40% (11 of 27), but this was significantly higher than the 0% (0 of 50) in control women without SBIs. These findings suggest that there is a chronic ongoing inflammatory process in some women with SBIs, the implications of which are discussed in the context of silicone as an antigenic stimulant of the immune system.
机译：通过酶免疫测定法检查了27例有硅胶乳房植入物（SBI）的妇女和50例年龄匹配的无SBI的对照妇女的血浆中白介素-1β（IL-1 beta）及其天然受体拮抗剂IL-1ra的存在。结果显示，有SBI的女性中有74％（27名中的20名）的IL-1ra浓度升高，而没有SBI的对照组中只有2％（50名中的1名）的IL-1ra浓度升高。与IL-1ra结果相反，患有SBI的女性中IL-1 beta浓度升高的频率仅为40％（27中的11），但显着高于没有SBI的女性中0％（50中的0）。 SBI。这些发现表明，一些患有SBI的女性正在经历一个慢性炎症过程，其影响在有机硅作为免疫系统的抗原刺激剂的背景下进行了讨论。

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