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首页> 外文期刊>Contrast media & molecular imaging >PET Imaging of Crossed Cerebellar Diaschisis after Long-Term Cerebral Ischemia in Rats
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PET Imaging of Crossed Cerebellar Diaschisis after Long-Term Cerebral Ischemia in Rats

机译：大鼠长期脑缺血后交叉小脑透析的PET成像

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Crossed cerebellar diaschisis (CCD) is a decrease of regional blood flow and metabolism in the cerebellar hemisphere contralateral to the injured brain hemisphere as a common consequence of stroke. Despite CCD has been detected in patients with stroke using neuroimaging modalities, the evaluation of this phenomenon in rodent models of cerebral ischemia has been scarcely evaluated so far. Here, we report the in vivo evaluation of CCD after long-term cerebral ischemia in rats using positron emission tomography (PET) imaging with 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG). Imaging studies were combined with neurological evaluation to assess functional recovery. In the ischemic territory, imaging studies showed a significant decrease in glucose metabolism followed by a progressive recovery later on. Conversely, the cerebellum showed a contralateral hypometabolism from days 7 to 14 after reperfusion. Neurological behavior showed major impaired outcome at day 1 after ischemia followed by a significant recovery of the sensorimotor function from days 7 to 28 after experimental stroke. Taken together, these results suggest that the degree of CCD after cerebral ischemia might be predictive of neurological recovery.
机译：交叉型小脑透析（CCD）是中风的常见后果，与受伤的脑半球对侧的小脑半球局部血流和代谢减少。尽管已使用神经影像学方法在卒中患者中检测到了CCD，但到目前为止，在脑缺血的啮齿类动物模型中对这种现象的评估还很少。在这里，我们报道使用2-脱氧-2- [18F]氟-D-葡萄糖（[18F] FDG）的正电子发射断层扫描（PET）成像对大鼠长期脑缺血后CCD的体内评估。影像学研究与神经系统评估相结合，以评估功能恢复。在缺血区域，影像学研究显示葡萄糖代谢显着下降，随后逐渐恢复。相反，小脑在再灌注后第7至14天表现出对侧代谢不足。在缺血性卒中后第1天，神经行为表现出严重的预后受损，随后在实验性中风后第7至28天，感觉运动功能明显恢复。综上所述，这些结果表明脑缺血后CCD的程度可能预示了神经功能的恢复。

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