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首页> 外文期刊>Acta Chirurgica Latviensis >First Results of using Stem Cell Transplantation for Pediatric Patients in Case of Dilated Cardiomyopathy
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First Results of using Stem Cell Transplantation for Pediatric Patients in Case of Dilated Cardiomyopathy

机译：小儿扩张性心肌病患者使用干细胞移植的初步结果

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First Results of using Stem Cell Transplantation for Pediatric Patients in Case of Dilated Cardiomyopathy Dilated cardiomyopathy is a serious disorder of the myocardium in pediatric age. Conservative therapy is limited and lethal outcome observed in one third of patients within a year. Bone marrow derived progenitor cell transplantation is becoming a promising method of treatment in adult population and there is ground to believe there are perspectives in pediatric cardiology.Aim of the Study. We present the first results of bone marrow cell transplantation in case of dilated cardiomyopathy for six patients at age four months to seventeen years.Materials and methods. We did the six Bone marrow derived progenitor cell (BMCs) intramycardial transplantations. Five to 30 mililiters of bone marrow were aspirated from iliac bone. Seventeen to 90 million BMCs were isolated and as suspension of physiologic saline given to patients by intramyocardial punction. Every patient underwent repeated examination every two month.Results. Six months following bone marrow derived progenitor stem cell intramyocardial transplantation we observed increase of ejection fraction in 4 patients, decrease of dilatation echocardiographycally and cardiothoracic ratio (CTR) at chest x-ray; decrease of the stage of heart insufficiency clinically from class IV to I-II(NYHA).Conclusions. We see the intramyocardial administration of bone marrow cells proved to be technically feasible and safe, also the procedure does not need for expensive technical equipment. The bone marrow transplantation improves the patients clinical situation and physical measurements. Our method might be used for the stabilization of the patient to get the time for further treatment.
机译：小儿心肌病患者使用干细胞移植的初步结果扩张型心肌病是小儿年龄段的一种严重的心肌疾病。保守治疗受到限制，一年内三分之一的患者观察到致死性结果。骨髓来源的祖细胞移植正在成为成人人群中一种有前途的治疗方法，并且有理由相信小儿心脏病学也存在一些观点。研究目的。我们介绍了在4个月至17岁时发生的6例扩张型心肌病患者的骨髓细胞移植的初步结果。材料和方法。我们进行了六次骨髓来源的祖细胞（BMC）心肌内移植。从骨抽吸出5至30毫升的骨髓。分离出了十七至九千万个BMC，并将其作为生理盐水的悬浮液通过心肌内点滴给予患者。每两个月对每个患者进行一次重复检查。骨髓祖细胞干细胞心肌移植后六个月，我们观察到4例患者的射血分数增加，超声心动图检查的扩张度和胸部X线检查的心胸比率（CTR）降低;临床上从IV级到I-II级（NYHA）的心脏功能不足阶段的减少。我们看到，骨髓内心肌细胞内给药在技术上是可行和安全的，而且该过程不需要昂贵的技术设备。骨髓移植改善了患者的临床状况和身体状况。我们的方法可能用于稳定患者，以便有时间进行进一步治疗。

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