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首页> 外文期刊>Czech Journal of Animal Science >The association of five polymorphisms with milk production traits in Czech Fleckvieh cattle
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The association of five polymorphisms with milk production traits in Czech Fleckvieh cattle

机译:捷克Fleckvieh牛的5个多态性与产奶性状的关联

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The aim of this study was to estimate allelic and genotypic frequencies of five DNA markers that are positional and functional candidates for milk production traits in Czech Fleckvieh cattle. In addition, we evaluated the association of these markers with milk production traits and breeding values for milk production traits and also estimated linkage disequilibrium (LD) between two markers within the prolactin ( PRL ) gene. As part of this study, 505 Czech Fleckvieh cows were genotyped. The markers in proliferator-activated receptor gamma coactivator 1-alpha ( PPARGC1A ), secreted phosphoprotein ( SPP1 ), cytochrome P450 family 11 subfamily B hydroxylase ( CYP11B1 ), and the two polymorphisms in the prolactin gene ( PRL ) showed evidence of segregation in our study. The PPARGC1A polymorphism was associated with milk yield, milk fat and protein traits. The polymorphism in SPP1 was significantly associated with milk protein percentage. The CYP11B1 polymorphism showed positive associations with milk composition traits and breeding values for milk yield, milk fat, and protein traits. Both polymorphisms within the PRL gene were associated with milk yield, milk fat and milk protein yield (individually and grouped). Linkage disequilibrium between the two polymorphisms in PRL was not observed. In conclusion, all markers examined in this study are important markers for milk production traits in Czech Fleckvieh cattle, and both markers within the PRL gene should be evaluated in future research.
机译:这项研究的目的是评估捷克Fleckvieh牛乳汁生产性状的五个位置和功能候选DNA标记的等位基因和基因型频率。此外,我们评估了这些标记物与乳汁生产性状和乳汁生产性状的育种值之间的关联,并评估了催乳素(PRL)基因中两个标记之间的连锁不平衡(LD)。作为这项研究的一部分,对505头捷克Fleckvieh母牛进行了基因分型。增殖物激活的受体γ共激活物1-alpha(PPARGC1A),分泌的磷蛋白(SPP1),细胞色素P450家族11亚家族B羟化酶(CYP11B1)的标记以及催乳素基因(PRL)的两个多态性表明在我们的分离证据研究。 PPARGC1A多态性与牛奶产量,牛奶脂肪和蛋白质性状有关。 SPP1中的多态性与牛奶蛋白百分比显着相关。 CYP11B1基因多态性与牛奶成分性状和产奶量,乳脂和蛋白质性状的育种值呈正相关。 PRL基因内的两个多态性均与牛奶产量,牛奶脂肪和牛奶蛋白质产量(单独和分组)相关。没有观察到PRL中两个多态性之间的连锁不平衡。总之,本研究中检验的所有标记物都是捷克Fleckvieh牛产奶性状的重要标记物,PRL基因中的两个标记物都应在未来研究中进行评估。

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