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首页> 外文期刊>Acta neurobiologiae experimentalis >Tiapride prevents the aversive but not the rewarding effect induced by parabrachial electrical stimulation in a place preference task
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Tiapride prevents the aversive but not the rewarding effect induced by parabrachial electrical stimulation in a place preference task

机译：替泊必利可防止在位置偏爱任务中由肱臂旁电刺激引起的反感效果而不是奖赏效果

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摘要

The parabrachial complex has been related to the processing of both rewarding and aversive signals. This pontine area is activated afterthe gastrointestinal administration of rewarding nutrients, in taste aversion learning, and in response to the reinforcing and aversiveeffects of some drugs of abuse. Electrical stimulation of this region can induce, in different animals, preference or aversion behaviorstowards a place in a rectangular three?chamber maze task. This study examined the effect of tiapride, a D2/D3 receptor antagonist, onthe aversive or rewarding effects induced by electrical stimulation of the external lateral parabrachial subnucleus (NLPBe). As previouslyobserved, administration of tiapride interrupted the aversive effect induced by NLPBe electrical stimulation. However, in contrast tothe effects of dopamine antagonists on other rewarding systems, tiapride did not impair the place preference induced by NLPBestimulation, an activation effect that is subject to tolerance. Tiapride administration also appeared to have no effect on the horizontalmotor activity (crossings) of the electrically stimulated animals. We discuss the specific relevance of parabrachial reward with respect toother reinforcing brain components or systems, especially in relation to the preference effect of drugs of abuse, such as opiates, afterdopamine antagonist administration.
机译：臂旁肌复合体与奖励信号和厌恶信号的处理有关。在胃肠道给予有益营养后，在厌恶味觉中，并响应某些滥用药物的增强和厌恶作用，激活该桥脑区。在不同的动物中，该区域的电刺激可以引起对矩形三室迷宫任务中某个位置的偏爱或厌恶行为。这项研究检查了D2 / D3受体拮抗剂tiapride对电刺激外侧臂外侧副臂旁核（NLPBe）引起的厌恶或奖励作用的影响。如先前所观察到的，施用tiapride中断了由NLPBe电刺激引起的厌恶作用。然而，与多巴胺拮抗剂对其他奖励系统的作用相反，替帕必利不损害由NLPBestimulation诱导的位置偏好，后者是一种耐受性的激活作用。施用Tiapride对电刺激动物的水平运动活动（交叉）似乎也没有影响。我们讨论了臂旁奖赏相对于其他增强性大脑组件或系统的具体相关性，特别是与滥用药物（如鸦片类药物，多巴胺拮抗剂）的偏爱作用有关。

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