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首页> 外文期刊>Acta neurobiologiae experimentalis >Tiapride prevents the aversive but not the rewarding effect induced by parabrachial electrical stimulation in a place preference task
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Tiapride prevents the aversive but not the rewarding effect induced by parabrachial electrical stimulation in a place preference task

机译：Tiapride防止厌恶但不是Parabrachial电气刺激在地方偏好任务中引起的奖励效果

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摘要

The parabrachial complex has been related to the processing of both rewarding and aversive signals. This pontine area is activated after the gastrointestinal administration of rewarding nutrients, in taste aversion learning, and in response to the reinforcing and aversive effects of some drugs of abuse. Electrical stimulation of this region can induce, in different animals, preference or aversion behaviors towards a place in a rectangular three-chamber maze task. This study examined the effect of tiapride, a D2/D3 receptor antagonist, on the aversive or rewarding effects induced by electrical stimulation of the external lateral parabrachial subnucleus (NLPBe). As previously observed, administration of tiapride interrupted the aversive effect induced by NLPBe electrical stimulation. However, in contrast to the effects of dopamine antagonists on other rewarding systems, tiapride did not impair the place preference induced by NLPBe stimulation, an activation effect that is subject to tolerance. Tiapride administration also appeared to have no effect on the horizontal motor activity (crossings) of the electrically stimulated animals. We discuss the specific relevance of parabrachial reward with respect to other reinforcing brain components or systems, especially in relation to the preference effect of drugs of abuse, such as opiates, after dopamine antagonist administration.
机译：Parabrachial Complex一直与奖励和厌恶信号的处理有关。这种猪面积在胃肠道营养成分的胃肠道后激活，在味道厌恶学习，以及对一些滥用药物的增强和厌恶作用。该区域的电刺激可以在不同的动物中诱导朝向矩形三室迷宫任务中的一个地方的偏好或厌恶行为。该研究检测了Tiapride，D2 / D3受体拮抗剂对由外侧桥次核（NLPBE）的电刺激诱导的厌恶或奖励效果的影响。如前所述，Tiapride的给药中断NLPBE电刺激诱导的厌血效果。然而，与多巴胺拮抗剂对其他有益系统的影响相反，TIAPRINE没有损害NLPBE刺激诱导的偏好，其受耐受性的激活效果。 TiApride给药还似乎对电刺激动物的水平电动机活动（交叉）没有影响。我们讨论了对其他加强脑成分或系统的近距离奖励的具体相关性，特别是在多巴胺拮抗剂给药后，例如鸦片药物的偏好效果。

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