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首页> 外文期刊>Acta neurobiologiae experimentalis >Marble burying as compulsive behaviors in male and female mice
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Marble burying as compulsive behaviors in male and female mice

机译：大理石埋葬作为雄性和雌性小鼠的强迫行为

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Marble burying is considered an, albeit controversial, animal model of the compulsive like behaviors of obsessive.compulsivedisorder (OCD). Hallmark features of OCD patients are similarities and, more prominent, differences from anxiety disorders, e.g., the absence of sex differences and resistance to spontaneous remission. We report an experiment on marble burying by male and female C57/BL6/N mice. Animals were administered either the classic anxiolytic drug, diazepam, that targets the GABA receptor ora “pure” inhibitor of the serotonin transporter, escitalopram, that has been reported to be particularly effective in OCD. A burying paradigm that more precisely mimics the human condition was used, e.g., testing in the home environment, chronic drug exposure and acknowledging individual differences by pre.selecting for high marble burying. Results were that there were no sex differences in groups treated with drugs or in control mice. Both diazepam and escitalopram decreased numbers of marbles buried compared to vehicle.only controls in the absence of correlated changes in anxiety. Diazepam, however, was more effective than escitalopram in suppressing MB. The conclusion is that along with serotonin, GABA is involved in regulating compulsive behaviors. The marble burying paradigm may prove more useful for pharmacological drugs tests of impulsivity or attention deficit because of the involvement of serotonin and GABA in both disorders.
机译：尽管有争议，大理石埋葬被认为是强迫性强迫症（OCD）行为的动物模型。 OCD患者的标志性特征是与焦虑症的相似性，并且更突出的是与焦虑症的区别，例如，没有性别差异和对自发缓解的抵抗力。我们报告了雄性和雌性C57 / BL6 / N小鼠进行大理石掩埋的实验。给动物服用了针对GABA受体的经典抗焦虑药地西epa或血清素转运蛋白依他普仑的“纯”抑制剂，据报道该抑制剂在强迫症中特别有效。使用了更精确地模仿人类状况的掩埋范例，例如在家庭环境中进行测试，长期吸毒并通过预先选择高度大理石掩埋来确认个体差异。结果是，用药物治疗的组或对照组的小鼠没有性别差异。与媒介物相比，地西epa和依西酞普兰都减少了埋藏的大理石数量，仅在没有相关性焦虑变化的情况下才进行。然而，地西p在抑制MB方面比依他普仑更有效。结论是，GABA与5-羟色胺一起参与调节强迫行为。由于5-羟色胺和GABA参与了这两种疾病，大理石掩埋范例可能被证明对冲动或注意力不足的药理学测试更为有用。

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