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首页> 外文期刊>Acta neurobiologiae experimentalis >Marble burying as compulsive behaviors in male and female mice
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Marble burying as compulsive behaviors in male and female mice

机译：大理石埋在男性和女性老鼠中的强迫行为

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摘要

Marble burying is considered an, albeit controversial, animal model of the compulsive like behaviors of obsessive-compulsive disorder (OCD). Hallmark features of OCD patients are similarities and, more prominent, differences from anxiety disorders, e.g., the absence of sex differences and resistance to spontaneous remission. We report an experiment on marble burying by male and female C57/BL6/N mice. Animals were administered either the classic anxiolytic drug, diazepam, that targets the GABA receptor or a "pure" inhibitor of the serotonin transporter, escitalopram, that has been reported to be particularly effective in OCD. A burying paradigm that more precisely mimics the human condition was used, e.g., testing in the home environment, chronic drug exposure and acknowledging individual differences by pre-selecting for high marble burying. Results were that there were no sex differences in groups treated with drugs or in control mice. Both diazepam and escitalopram decreased numbers of marbles buried compared to vehicle-only controls in the absence of correlated changes in anxiety. Diazepam, however, was more effective than escitalopram in suppressing MB. The conclusion is that along with serotonin, GABA is involved in regulating compulsive behaviors. The marble burying paradigm may prove more useful for pharmacological drugs tests of impulsivity or attention deficit because of the involvement of serotonin and GABA in both disorders.
机译：大理石埋葬被认为是一个强迫性强迫症的强迫性行为的争议，争议的动物模型（OCD）。 OCD患者的标志特征是相似之处，更突出，焦虑症的差异，例如，没有性差异和对自发缓解的抵抗力。我们在雄性和雌性C57 / BL6 / N小鼠上举报了大理石埋葬的实验。将动物施用经典疾病药物，DiazePAM，其针对GABA受体或血清素转运蛋白转运蛋白的“纯”抑制剂，据报道，据报道，在OCD中特别有效。使用更精确模仿人体状况的埋地范式，例如，在家庭环境中测试，慢性药物暴露和通过预选择高大理石埋葬来承认个人差异。结果是药物或对照小鼠治疗的群体中没有性差异。在没有相关变化的焦虑变化的情况下，Diazepam和Escinalopram均降低了与车辆的控制相比埋藏的大理石数量下降。然而，在抑制MB时，Diazepam比escitalopram更有效。结论是与血清素一起，加巴巴参与调节强迫行为。由于血清素和GABA在两种疾病中的参与，大理石埋弧范式可能对脉冲性或注意力缺陷的试验更有用。

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