Significant alterations of the cranio-orofacial region have been observed in subjects with Down’s syndrome. The aim of this study was to assess the frequency of particular orthodontic malocclusion in these subjects. A group of 112 subjects with cytogenetically confirmed diagnosis of Down’s syndrome was examined. All the subjects underwent a complete dental examination. The following classification was used to determine malocclusion of crowding, premature tooth loss, class III malocclusion, open bite, class II division 2 malocclusion, unilateral cross bite and bilateral cross bite. Clipper language programs were designed for data processing. Malocclusion was found in 92% of the subjects. Class III malocclusion was most frequently observed (43.8%). Crowding and unilateral cross bite were found in 15% of the subjects respectively. Bilateral cross bite was present in 5.4% of the subjects. Premature tooth loss was observed in only 1% of the subjects whereas class II division 2 malocclusion was not recorded in any of the subjects examined.
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