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首页> 外文期刊>Advances in Epidemiology >Isoniazid Preventive Therapy Adherence and Associated Factors among HIV Positive Patients in Addis Ababa, Ethiopia
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Isoniazid Preventive Therapy Adherence and Associated Factors among HIV Positive Patients in Addis Ababa, Ethiopia

机译：埃塞俄比亚亚的斯亚贝巴HIV阳性患者的异烟肼预防性治疗依从性及相关因素

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Tuberculosis coinfected with HIV constitutes a large proportion of patients in Ethiopia. Isoniazid preventive therapy (IPT) is recommended for the treatment of latent tuberculosis infection. However, the level of IPT adherence and associated factors among people living with HIV (PLHIV) have not been well explored. This study aimed to assess adherence to IPT and associated factors among PLHIV in Addis Ababa. Facility based cross-sectional study was conducted. The study was conducted in 10 health centers and 2 hospitals. Patients were consecutively recruited till the required sample size was obtained. From 406 PLHIV approached, a total of 381 patients on IPT were interviewed. Data were entered and analyzed using Epi-Info version 3.5 and SPSS version 16. The level of adherence to IPT was 89.5%. Patients who have taken isoniazid for ≥5 months were more likely to be adherent than those who took it for 1-2 months [AOR (95%CI) = 5.09 (1.41–18.36)]. Patients whose friends decide for them to start IPT were less likely to be adherent than others [AOR (95%CI) = 0.10 (0.01–0.82)]. The level of adherence to IPT in PLHIV was high. Counseling of patients who are in their first two months of therapy should be more strengthened. Strong Information Education Communication is essential to further enhance adherence.
机译：合并感染艾滋病毒的结核病在埃塞俄比亚占很大比例的患者。建议使用异烟肼预防性治疗（IPT）来治疗潜伏性结核感染。但是，尚未充分探讨艾滋病毒感染者（IPHIV）中IPT依从性的水平和相关因素。这项研究旨在评估亚的斯亚贝巴的艾滋病毒感染者对IPT的依从性和相关因素。进行了基于设施的横断面研究。这项研究是在10个健康中心和2家医院进行的。连续招募患者直到获得所需的样本量。从406名PLHIV患者中，总共对381名IPT患者进行了访谈。使用Epi-Info版本3.5和SPSS版本16输入和分析数据。对IPT的遵守程度为89.5％。服用异烟肼≥5个月的患者比接受1-2个月的患者更有可能坚持治疗[AOR（95％CI）= 5.09（1.41–18.36）]。朋友决定让他们开始IPT的患者比其他患者更难以依从[AOR（95％CI）= 0.10（0.01–0.82）]。 PLHIV对IPT的依从性很高。在治疗的头两个月中，应进一步加强对患者的咨询。强有力的信息教育沟通对于进一步提高遵守率至关重要。

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