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首页> 外文期刊>ACS Omega >New Fast, Highly Selective Probe with Both Aggregation-Induced Emission Enhancement and Intramolecular Charge-Transfer Characteristics for Homocysteine Detection
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New Fast, Highly Selective Probe with Both Aggregation-Induced Emission Enhancement and Intramolecular Charge-Transfer Characteristics for Homocysteine Detection

机译：具有集聚诱导的发射增强和同型半胱氨酸检测的分子内电荷转移特性的新型快速，高选择性探针

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摘要

A new fluorescence probe 2-(4′-(diphenylamino)-[1,1-biphenyl]-4-yl)-2H-[1,2,3]-triazole-4-carbaldehyde (DBTC) was designed and synthesized through Suzuki coupling reaction between (4-(diphenylamino)phenyl)boronic acid and (4-bromophenyl)-2H-[1,2,3]-triazole-4-carbaldehyde. This probe DBTC had intramolecular charge transfer and aggregation-induced emission enhancement performances and showed high selectivity and sensitivity toward homocysteine (Hcy) in the presence of other amino acids. The detection limit of probe DBTC for Hcy was 3.05 × 10–6 M, and the mechanism was researched by 1H NMR titration experiments and mass spectrometry. Furthermore, cell-culture results indicated that probe DBTC was cell permeable and could be used to detect Hcy in living cells. The good characteristics of the probe DBTC had huge application potential use for researching the effects of Hcy in other biological systems.
机译：设计并合成了一种新型的荧光探针2-（4'-（二苯氨基）-[1,1-联苯] -4-基）-2H- [1,2,3]-三唑-4-甲醛（DBTC） （4-（二苯基氨基）苯基）硼酸与（4-溴苯基）-2H- [1,2,3]-三唑-4-甲醛之间的Suzuki偶联反应。该探针DBTC具有分子内电荷转移和聚集诱导的发射增强性能，并且在存在其他氨基酸时显示出对同型半胱氨酸（Hcy）的高选择性和敏感性。 Hcy探针DBTC的检出限为3.05×10-6 M，并通过1 H NMR滴定实验和质谱研究了机理。此外，细胞培养结果表明探针DBTC具有细胞渗透性，可用于检测活细胞中的Hcy。 DBTC探针的优良特性在研究Hcy在其他生物系统中的作用方面具有巨大的应用潜力。

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