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首页> 外文期刊>Advances in Orthopedics >Increasing Resistance of Coagulase-Negative Staphylococci in Total Hip Arthroplasty Infections: 278 THA-Revisions due to Infection Reported to the Norwegian Arthroplasty Register from 1993 to 2007
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Increasing Resistance of Coagulase-Negative Staphylococci in Total Hip Arthroplasty Infections: 278 THA-Revisions due to Infection Reported to the Norwegian Arthroplasty Register from 1993 to 2007

机译：凝固酶阴性葡萄球菌在全髋关节置换术感染中的耐药性增加：278 THA-由于感染引起的修订报告从1993年至2007年向挪威人工关节置换术登记

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We investigated bacterial findings from intraoperative tissue samples taken during revision due to infection after total hip arthroplasty (THA). The aim was to investigate whether the susceptibility patterns changed during the period from 1993 through 2007. Reported revisions due to infection in the Norwegian Arthroplasty Register (NAR) were identified, and 10 representative hospitals in Norway were visited. All relevant information on patients reported to the NAR for a revision due to infection, including bacteriological findings, was collected from the medical records. A total of 278 revision surgeries with bacterial growth in more than 2 samples were identified and included. Differences between three 5-year time periods were tested by the chi-square test for linear trend. The most frequent isolates were coagulase-negative staphylococci (CoNS) (41%, 113/278) andStaphylococcus aureus(19%, 53/278). The proportion of CoNS resistant to the methicillin-group increased from 57% (16/28) in the first period, 1993–1997, to 84% (52/62) in the last period, 2003–2007 (P= 0.003). There was also significant increase in resistance for CoNS to cotrimoxazole, quinolones, clindamycin, and macrolides. AllS. aureusisolates were sensitive to both the methicillin-group and the aminoglycosides. For the other bacteria identified no changes in susceptibility patterns were found.
机译：我们调查了由于全髋关节置换术（THA）感染而在翻修期间从术中采集的组织样本中的细菌发现。目的是调查在1993年至2007年期间是否易感性模式发生变化。确定了挪威人工关节成形术登记册（NAR）因感染引起的报告修订，并访问了挪威的10家代表性医院。从病历中收集了所有因感染而向NAR报告进行修订的患者的相关信息，包括细菌学发现。总共鉴定并纳入了278个翻修手术，其中细菌生长在两个以上的样本中。通过卡方检验来检验三个5年时间段之间的差异，以得出线性趋势。最常见的分离株是凝固酶阴性葡萄球菌（CoNS）（41％，113/278）和金黄色葡萄球菌（19％，53/278）。对甲氧西林组耐药的CoNS比例从1993-1997年第一个时期的57％（16/28）增加到2003-2007年最后一个时期的84％（52/62）（P = 0.003）。 CoNS对科曲唑，喹诺酮类，克林霉素和大环内酯类药物的耐药性也显着增加。 AllS。金黄色葡萄球菌对甲氧西林和氨基糖苷均敏感。对于鉴定出的其他细菌，未发现敏感性模式的变化。

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