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Prevalence and factors associated with diagnosis of early rheumatoid arthritis in the south of Brazil

机译:巴西南部早期风湿性关节炎的诊断及相关因素

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Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by peripheral and symmetrical polyarthritis. It can be divided into Very Early Rheumatoid Arthritis (VERA) diagnosed up to 3 months of symptoms and late onset (Late Early Rheumatoid Arthritis – LERA), diagnosed between 3 and 12 months. Currently, it is recommended to evaluate the patient with joint symptoms as early as possible, and the first 12 weeks of manifestations represent the ideal phase for the diagnosis, favoring a better evolution of the treatment. The present study aimed to determine the prevalence of early diagnosis of rheumatoid arthritis, mean time of diagnosis and to determine possible associated factors in the municipality of Blumenau, Santa Catarina, Brazil. A cross-sectional study using the 1987 American College of Rheumatology diagnostic criteria to select patients attended at primary or secondary health care units in Blumenau, Santa Catarina, southern Brazil, in 2014. Diagnostic time was verified by self-report of the time elapsed between the onset of symptoms and the diagnosis made by a rheumatologist. To test the associations, the chi-square test, the Wald linear trend test and the Poisson regression analysis were used. The mean time of diagnosis was 28 months. The prevalence of diagnosis up to 3 and 12 months was 27.7% and 64.8%, respectively. Obesity was associated with time diagnosis in both periods. The 0–4 years category of the variable education was associated only with the period up to 12 months. The mean time of diagnosis was similar to the national context. Among socioeconomic factors, lower education was associated with the diagnosis of late onset RA. The anthropometric variable presented a progressive increase in the prevalence due to the longer time to diagnosis.
机译:类风湿关节炎(RA)是一种自身免疫性炎性疾病,其特征是周围性和对称性多关节炎。它可以分为诊断为症状长达3个月的非常早期类风湿关节炎(VERA)和诊断为3至12个月的晚期早期类风湿关节炎-LERA。当前,建议尽早评估患有关节症状的患者,表现的前12周代表诊断的理想阶段,有利于更好的治疗方案。本研究旨在确定类风湿关节炎的早期诊断患病率,平均诊断时间并确定巴西圣卡塔琳娜州布鲁梅瑙市的可能相关因素。这项横断面研究采用了1987年美国风湿病学会的诊断标准,以选择2014年在巴西南部圣卡塔琳娜州布鲁梅瑙参加初级或二级卫生保健部门就诊的患者。诊断时间通过自我报告的时间间隔进行验证风湿病的症状发作和诊断。为了检验关联,使用卡方检验,Wald线性趋势检验和泊松回归分析。平均诊断时间为28个月。截至3个月和12个月的诊断患病率分别为27.7%和64.8%。肥胖与两个时期的时间诊断有关。可变教育的0–4年类别仅与12个月以下的时间段相关。平均诊断时间与国家情况相似。在社会经济因素中,低学历与迟发性RA的诊断有关。由于更长的诊断时间,人体测量学变量显示患病率逐渐增加。

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