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首页> 外文期刊>African Journal of Biotechnology >Anti-obesity and hypolipidemic effects of a functional formula containing Prumus mume in mice fed high-fat diet
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Anti-obesity and hypolipidemic effects of a functional formula containing Prumus mume in mice fed high-fat diet

机译：高脂饮食喂养的含鼠李功​​能配方的抗肥胖和降血脂作用

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摘要

The present study is designed to investigate the effect of?an anti-obesity functional formula (PMC) composed of?Prumus?mume?stem barks extract (PMSBE)?and L-carnitine (2:1, w/w) on?obesity and hyperlipidemia induced by high-fat diet in mice.Male ICR mice were fed a high-fat diet (HFD) with or without PMC (PMC-1 group: 450 mg/kg/day; PMC-2 group: 900 mg/kg/day) for 6 weeks to examine adipose tissue weight, serum lipid profile, and the pathological changes in liver tissue. The results showed that body weight gain was significantly lowered in PMC groups compared with the HFD group. PMC could improve lipid profile by lowering serum total cholesterol (Total-C), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C) concentrations, and increasing high-density lipoprotein cholesterol (HDL-C) concentration as compared with the HFD group. PMC also improved the pathological changes in liver tissue, decreased the relative weights of epididymal and perirenal WAT.?Our findings suggest that?PMC has significantly anti-obesity and hypolipidemic effects.
机译：本研究旨在研究由“香豆”，“茎茎皮提取物”（PMSBE）和左旋肉碱（2：1，w / w）组成的抗肥胖功能配方（PMC）对肥胖的影响对ICR雄性小鼠饲喂高脂饮食（HFD）或不添加PMC（PMC-1组：450 mg / kg /天; PMC-2组：900 mg / kg /天），共6周，以检查脂肪组织重量，血清脂质分布和肝组织的病理变化。结果显示，与HFD组相比，PMC组的体重增加显着降低。 PMC可以通过降低血清总胆固醇（Total-C），三酰甘油（TG），低密度脂蛋白胆固醇（LDL-C）浓度和增加高密度脂蛋白胆固醇（HDL-C）浓度来改善脂质分布。 HFD组。 PMC还改善了肝脏组织的病理变化，降低了附睾和肾周WAT的相对重量。我们的研究结果表明PMC具有明显的抗肥胖和降血脂作用。

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