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首页> 外文期刊>BMB Reports >Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition
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Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition

机译：大黄大黄通过蛋白质酪氨酸磷酸酶1B抑制高脂饮食喂养的C57BL / 6小鼠的抗肥胖和降血脂作用

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Protein tyrosine phosphatase 1B (PTP1B) is important in the regulation of metabolic diseases and has emerged as a promising signaling target. Previously, we reported the PTP1B inhibitory activity of Rheum undulatum (RU). In the present study, we investigated the metabolic regulatory effects of RU in a high-fat diet (HFD) model. RU treatment significantly blocked body weight gain, which was accompanied by a reduction of feed efficiency. In addition, it led to a reduction of liver weight mediated by overexpression of PPARα and CPT1 in the liver, and an increase in the expression of adiponectin, aP2, and UCP3 in adipose tissue responsible for the reduction of total and LDL-cholesterol levels. Chrysophanol and physcion from RU significantly inhibited PTP1B activity and strongly enhanced insulin sensitivity. Altogether, our findings strongly suggest that 2 compounds are novel PTP1B inhibitors and might be considered as anti-obesity agents that are effective for suppressing body weight gain and improving lipid homeostasis.
机译：蛋白酪氨酸磷酸酶1B（PTP1B）在代谢疾病的调节中很重要，并且已成为有希望的信号靶标。以前，我们报道了大黄大黄（RU）的PTP1B抑制活性。在本研究中，我们调查了高脂饮食（HFD）模型中RU的代谢调节作用。 RU处理显着阻止了体重增加，并伴有饲料效率下降。此外，它导致肝脏中PPARα和CPT1过表达介导的肝脏重量减少，以及导致总和LDL胆固醇水平降低的脂肪组织中脂联素，aP2和UCP3的表达增加。 RU中的酚和physcion显着抑制了PTP1B活性并大大增强了胰岛素敏感性。总而言之，我们的发现强烈暗示了2种化合物是新型PTP1B抑制剂，可以被认为是有效抑制体重增加和改善脂质稳态的抗肥胖药。

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