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首页> 外文期刊>African Journal of Biotechnology >Antinociceptive and anti-inflammatory activities of the aqueous extract of the root bark of Combretum sericeum in rodents
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Antinociceptive and anti-inflammatory activities of the aqueous extract of the root bark of Combretum sericeum in rodents

机译：鼠尾草根皮水提物对啮齿动物的镇痛和抗炎活性

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Combretum sericeum?(Combretacae) is used traditionally in Northern Nigeria for the treatment of fever. In this study, the activities of the aqueous extract of the root bark of this plant against nociception and inflammation were investigated in mice and rats. The studies were carried out using acetic acid writhing, hot plate algesia and carrageenan induced inflammation in rats. The results showed that the extract exhibited significant (P < 0.001) anti-nociceptive and anti-inflammatory activities in all the models used. Phytochemical screening of the extract revealed the presence of tannins, flavonoids, glycosides alkaloids and anthraquinones. The intraperitoneal median lethal dose (LD50) of the extract was found to be 177.48 mg/kg in mice. The observed activities might be the scientific basis for the traditional use of the plant in the treatment of fever. This study also paves way for the possible development of the plant extract as a phytodrug against pain and inflammatory conditions.
机译：Combretum sericeum？（Combretacae）在尼日利亚北部传统上用于治疗发烧。在这项研究中，在小鼠和大鼠中研究了该植物根皮的水提物对伤害感受和炎症的活性。这项研究是使用乙酸扭绞，热板痛觉过敏和角叉菜胶诱导的大鼠炎症进行的。结果表明，在所有使用的模型中，提取物均表现出显着的（P <0.001）抗伤害性和抗炎活性。提取物的植物化学筛选显示出单宁，类黄酮，糖苷生物碱和蒽醌的存在。在小鼠中，提取物的腹膜内中位致死剂量（LD50）为177.48 mg / kg。观察到的活动可能是植物在发烧中的传统用途的科学依据。这项研究也为植物提取物作为抗疼痛和炎性疾病的植物药的开发铺平了道路。

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