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Nutritional characteristics of guava leaves and its effects on lipid metabolism in hypercholesterolemic rats

机译:高胆固醇血症大鼠番石榴叶片的营养特性及其对脂质代谢的影响

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The objective of this study was to evaluate antioxidant substances, dietary fiber and antioxidant activity of guava leaves, and evaluate their amelioration hypercholesterolemia in rats. The leaves were dried and crushed into granulated powder. The active ingredient of the leaf powder was extracted by an ethanol/acetone mixture and called ethanol/acetone extract flour. Dietary fiber, vitamin C, beta-carotene, phenolic compounds and antioxidant activity were determined in the flours. Thirty (30) rats were used in the present study and categorized into: hypercholesterolemic control, non-hypercholesterolemic rats treated with ethanol/acetone extract flour, hypercholesterolemic rats treated with ethanol/acetone extract flour, non-hypercholesterolemic rats treated with leaf flours, and hypercholesterolemic rats treated with leaf flours. The animals were subjected to experimental hypercholesterolemia and treatment with flours for 42 days. At the end of the treatment, liver weight index versus body weight index, total hepatic lipids, C reactive protein, total cholesterol and fractions were evaluated. The treated hypercholeterolemic animals showed a reduction in total and fractionated cholesterol levels, but no difference was observed in the ratio liver weight index versus body weight index, total hepatic lipids and C reactive protein. It is concluded that guava leaves are a significant source of dietary fiber, phenolic compounds, vitamin C, beta-carotene, besides presenting antioxidant activity and hypocholesterolemic potential.
机译:这项研究的目的是评估番石榴叶的抗氧化物质,膳食纤维和抗氧化活性,并评估其改善大鼠高胆固醇血症的能力。将叶子干燥并压碎成颗粒状粉末。叶粉的活性成分用乙醇/丙酮混合物提取,称为乙醇/丙酮提取粉。测定了面粉中的膳食纤维,维生素C,β-胡萝卜素,酚类化合物和抗氧化活性。在本研究中使用了三十(30)只大鼠,分为:高胆固醇血症对照,乙醇/丙酮提取物面粉处理的非高胆固醇血症大鼠,乙醇/丙酮提取物面粉处理的非高胆固醇血症大鼠,叶粉处理的非高胆固醇血症大鼠和用叶粉治疗的高胆固醇血症大鼠。使动物经历实验性高胆固醇血症并用面粉处理42天。在治疗结束时,评估肝脏重量指数与体重指数,总肝脂质,C反应蛋白,总胆固醇和分数。经治疗的高胆固醇血症动物显示总胆固醇水平和分数胆固醇水平降低,但在肝脏重量指数与体重指数,总肝脂质和C反应蛋白的比率上未观察到差异。得出的结论是,番石榴叶除了具有抗氧化活性和降胆固醇潜力外,还是膳食纤维,酚类化合物,维生素C,β-胡萝卜素的重要来源。

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