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首页> 外文期刊>African Journal of Biotechnology >Pharmacognostic evaluation and antisickling activity of the leaves of Securinega virosa Roxb. ex Willd. (Euphorbiaceae)
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Pharmacognostic evaluation and antisickling activity of the leaves of Securinega virosa Roxb. ex Willd. (Euphorbiaceae)

机译：虎尾草叶的药理学评价和抗刺活性。前威尔德。 （大戟科）

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Securinega virosa (Euphorbiaceae) together with condiments from natural sources serve as antisickling remedies in Nigeria. This study was aimed at establishing the pharmacognostic profile as well as the antisickling activity of the leaves of S. virosa Roxb. ex Willd (Euphorbiaceae). Evaluation of the fresh, powdered and anatomical sections of the leaves were carried out to determine the macromorphological, micromorphological and chemomicroscopic characters. Chemical tests were employed in phytochemical investigations. Evaluation of the antisickling activity involved the inhibition of sodium metabisulphite-induced sickling of the HbSS red blood cells obtained from confirmed sickle cell patients who were not in crises. Concentrations of the crude extract and its fractions were tested with normal saline and p-hydroxybenzoic acid serving as controls. Microscopical studies showed anomocytic stomata arrangement and glandular trichomes. Phytochemical evaluation revealed the presence of tannins, flavonoids, alkaloids, saponins and cardiac glycosides. Percentage sickling inhibitions of the aqueous methanol extract of S. virosa as well as all the fractions, except the petroleum ether fractions were significant all through the period of assay p < 0. 05 compared to normal saline. These results are suggestive of a potential role for S. virosa in the management of sickle cell disorders and a candidate for further investigations.
机译：Securinega virosa（Euphorbiaceae）与天然调味品一起在尼日利亚用作抗镰剂。这项研究的目的是建立S. virosa Roxb叶片的药理学特征以及抗病活性。前Will（大戟科）。对叶片的新鲜，粉状和解剖切片进行评估，以确定其宏观形态，微观形态和化学显微镜特性。化学测试用于植物化学研究。抗镰刀菌活性的评估涉及抑制亚硫酸氢钠诱导的HbSS红细胞的镰刀切，该镰刀是从未患病的已确认镰刀细胞患者中获得的。用生理盐水和对羟基苯甲酸作为对照测试粗提物及其馏分的浓度。显微研究显示，单核细胞气孔排列和腺毛状体。植物化学评估显示单宁，类黄酮，生物碱，皂苷和强心苷的存在。与石油生理盐水相比，整个试验期间，除石油醚馏分外，链球菌甲醇提取物以及所有馏分的镰刀形抑制百分数均显着（p <0。05）。这些结果表明，维氏链球菌在镰状细胞疾病的治疗中具有潜在作用，并且是进一步研究的候选者。

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