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首页> 外文期刊>African Journal of Biotechnology >Increased COX-2 expression in patients with ovarian cancer
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Increased COX-2 expression in patients with ovarian cancer

机译：卵巢癌患者中COX-2表达增加

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The pathogenesis of ovarian cancer remains poorly understood. Genome-wide gene expression profiling can provide novel genetic data involved in the pathogenesis of disease.?In this study,?using normal?ovarian surface epithelium?and abnormal?ovarian surface epithelium?of patients with ovarian cancer as models for cDNA microarray analysis, we found that cyclooxygenase-2(COX-2) expression of patients with ovarian cancer was increased. This result was further confirmed by semi-quantitative RT- PCR and Western blot.?It was found that?COX-2?was significantly up-regulated in?ovarian cancer group?in comparison with?normal?group on mRNA level. On protein level,?COX-2?was also highly increased in?ovarian cancer group.?This study provides novel candidate molecules and suggests a potential local role for?COX-2?as mediators?of ovarian cancer and as markers of disease activity.
机译：卵巢癌的发病机理仍然知之甚少。全基因组基因表达谱分析可以提供涉及疾病发病机制的新遗传数据。在这项研究中，以卵巢癌患者的正常卵巢表面上皮和异常卵巢表面上皮为模型进行cDNA微阵列分析，我们发现卵巢癌患者的环氧合酶-2（COX-2）表达增加。通过半定量RT-PCR和Western印迹进一步证实了该结果。发现在卵巢癌组中，与正常组相比，COX-2在mRNA水平上显着上调。在蛋白质水平上，“ COX-2”在卵巢癌组中也高度增加。这项研究提供了新颖的候选分子，并暗示了“ COX-2”作为卵巢癌的介质和疾病活动的标志物的潜在局部作用。 。

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