Synthesis, characterization and antibacterial screening of 2,4-diaminopyrimidine pyrimethamine and trimethoprim silver complexes

Omoruyi G. Idemudia; Peter A. Ajibade; Anthony I. Okoh

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Synthesis, characterization and antibacterial screening of 2,4-diaminopyrimidine pyrimethamine and trimethoprim silver complexes

机译：2,4-二氨基嘧啶乙胺嘧啶和甲氧苄啶银配合物的合成，表征和抗菌筛选

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Air stable silver Ag(I) complexes of pyrimethamine and trimethoprim drugs have been synthesized and characterized by elemental analysis, Fourier transform infrared (FTIR) and ultraviolet visible (UV-Vis) spectroscopy, and conductivity measurement. The metal complexes formed a three and four coordinate geometry with the ligands acting as a monodentate molecule bonding to the silver ion in each case through the pyrimidine N (1) nitrogen. The complexes have non-electrolyte behaviour in dimethylformamide (DMF) solution with its low conductivity values. Silver complexes, their free ligands alongside the corresponding silver salts were screened against selected bacterial isolates. All the silver complexes showed enhanced antibacterial activities compared to their free ligands and potential antibacterial agents have been identified.

机译：通过元素分析，傅立叶变换红外光谱（FTIR）和紫外可见光谱（UV-Vis）以及电导率测量，合成了乙胺嘧啶和甲氧苄氨嘧啶药物的空气稳定的银Ag（I）配合物并进行了表征。金属络合物形成三坐标和四坐标的几何结构，配体作为单齿分子，分别通过嘧啶N（1）氮与银离子键合。该络合物在二甲基甲酰胺（DMF）溶液中具有非电解质行为，具有低电导率值。针对选定的细菌分离物筛选了银络合物，其游离配体以及相应的银盐。与它们的游离配体相比，所有的银络合物均显示出增强的抗菌活性，并且已经发现了潜在的抗菌剂。

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《African Journal of Biotechnology》 |2012年第39期|共7页
作者
Omoruyi G. Idemudia; Peter A. Ajibade; Anthony I. Okoh;
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中图分类生物工程学（生物技术）;
关键词
Pyrimethaminetrimethoprimsilver complexesantibacterial screeningminimum inhibitory concentration;

机译：乙胺三甲氧苄银复合物抗菌筛选最低抑菌浓度;

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Synthesis, characterization and antibacterial screening of 2,4-diaminopyrimidine pyrimethamine and trimethoprim silver complexes

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