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首页> 外文期刊>African Journal of Food, Agriculture, Nutrition and Development >Effect of african potato ( hypoxis hemerocallidea ) extract on oxidative stress induced by chloroquine in albino rats
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Effect of african potato ( hypoxis hemerocallidea ) extract on oxidative stress induced by chloroquine in albino rats

机译：非洲马铃薯（hypoxis hemerocallidea）提取物对氯喹致白化病大鼠氧化应激的影响。

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This study evaluated the antioxidant and protective effects of Hypoxis hemerocallidea Fisch. & C. A. Mey. (Hypoxidaceae) Corm ('African potato') water extract (HH) against chloroquine induced oxidative stress in albino rats. Chloroquine has been known to generate oxidative stress when used for different types of treatment like malaria, prophylactic treatment and treatment of rheumatoid arthritis. There is also biomedical evidence that African potato corm extracts possess anti-inflammatory, anti-nociceptive, antioxidant and anti-diabetic properties in vivo and in vitro. Twenty five albino rats were used for this study and were divided into five groups; chloroquine control group (CQ) received choroquine (25 mg/kg every day), normal control group (NC) received distilled water every day, normal experimental group (HYP) received water decoction of corm (10 ml/kg), two experimental groups (E1 and E2) received chloroquine (25 mg/kg) plus 10 ml and 20 ml of extract kg-1 body weight respectively. The experiment was conducted for a period of 30 days after which the rats were killed under ether anaesthesia, blood collected and liver removed for the measurement of thiobarbituric acid reactive substance, serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, reduced glutathione, superoxide dismutase, glutathione per-oxidase and tocopherol. The result showed that the water extract maintained the normal non enzymatic and enzymatic anti oxidants status and thus protected the rats in two experimental groups from oxidative stress generated due to chloroquine in dose dependant manner (P<0.001). The extract also increased the levels of reduced glutathione and tocopherol in HYP group (P<0.0001). It appears that under normal condition, H hemerocallidea acts as booster plant to antioxidant system increasing the levels of GSH and tocopherol. Thus from this study it can be concluded that H. hemerocallidea has potentials to protect the organism from oxidative stress generated by chloroquine and also to strengthen the antioxidant system under normal conditions.
机译：这项研究评估了Hypoxis hemerocallidea Fisch的抗氧化和保护作用。 ＆C. A. Mey。 （Hypoxidaceae）球茎（“非洲马铃薯”）水提取物（HH）对抗氯喹诱导的白化病大鼠的氧化应激。已知氯喹用于不同类型的治疗（例如疟疾，预防性治疗和类风湿关节炎）时会产生氧化应激。还有生物医学证据表明，非洲马铃薯球茎提取物在体内和体外均具有抗炎，抗伤害，抗氧化和抗糖尿病的特性。 25只白化病大鼠用于该研究，分为五组;每组5只。氯喹对照组（CQ）每天接受氯喹（25 mg / kg），正常对照组（NC）每天接受蒸馏水，正常实验组（HYP）接受球茎水煎汤（10 ml / kg），两个实验组（E1和E2）分别接受氯喹（25 mg / kg）加10 ml和20 ml提取物kg-1体重。实验进行了30天，之后在乙醚麻醉下处死大鼠，收集血液并取出肝脏以测定硫代巴比妥酸反应性物质，血清谷氨酸草酰乙酸转氨酶，血清谷氨酸丙酮酸转氨酶，还原性谷胱甘肽，超氧化物歧化酶，谷胱甘肽过氧化物酶和生育酚。结果表明，水提取物保持正常的非酶和酶抗氧化剂状态，从而以剂量依赖的方式保护了两个实验组的大鼠免受氯喹引起的氧化应激的影响（P <0.001）。提取物还增加了HYP组的还原型谷胱甘肽和生育酚水平（P <0.0001）。看起来在正常条件下，半边H属植物可作为抗氧化剂系统的增强植物，从而增加GSH和生育酚的含量。因此，从这项研究中可以得出结论，H。hemerocallidea有潜力保护生物体免受氯喹产生的氧化应激，并在正常条件下增强抗氧化系统。

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