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首页> 外文期刊>AIDS Research and Therapy >Determinants to antiretroviral treatment non-adherence among adult HIV/AIDS patients in northern Ethiopia
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Determinants to antiretroviral treatment non-adherence among adult HIV/AIDS patients in northern Ethiopia

机译：埃塞俄比亚北部成人HIV / AIDS患者抗逆转录病毒疗法治疗依从性不佳的决定因素

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Background Adhering 95% and above of antiretroviral therapy reduces the rate of disease progression and death among people’s living human immunodeficiency virus. Though manifold factors have reported as determinant factors of antiretroviral therapy adherence status, perhaps determinants of non-adherence differ up on the activities of patients in the study setting. Methods An institution based unmatched case–control study was conducted in Aksum town. Individuals who had a 6-month follow-up with complete individual information were included in the study. Document review and interviewer based techniques were used to collect the data. Binary logistic regression analysis was used to identify the determinant factors of non-adherence. Results A total of 411 (137 cases and 274 control) study participants were included in the study. The majority of them were male in sex. Having 2?years and above duration on ART [AOR?=?7, 95% CI (2.2, 22.6)], history of adverse effect [AOR?=?6.9, 95% CI (1.4, 32.9)], substance use [AOR?=?5.3, 95% CI (1.4, 20.0)], living with parents [AOR?=?3.4, 95% CI (1.2, 10.3)], having depression symptom [AOR?=?3.3, 95% CI (1.4, 7.5)],?3 cluster of differentiation 4 count [AOR?=?3.2, 95% CI (1.8, 5.8)] and low dietary diversity [AOR?=?2, 95% CI (1.1, 3.7)] were found significant determinants of non-adherence to antiretroviral drug. Conclusion Program, social and individual related factors showed a statistically significant associated with non-adherence to antiretroviral therapy. Managing lifestyle by developing self-efficacy of individuals and treating related threat to improve adherence status of antiretroviral therapy is recommended in this study.
机译：背景技术坚持使用95％或以上的抗逆转录病毒疗法可降低人们生存的人类免疫缺陷病毒的疾病进展和死亡率。尽管多种因素已被报告为抗逆转录病毒疗法依从性状态的决定因素，但在研究环境中，不依从性的决定因素在患者活动方面可能有所不同。方法在阿克苏姆镇进行了一项基于机构的无与伦比的病例对照研究。这项研究包括对患者进行了为期6个月的随访并提供了完整的个人信息的个体。使用基于文档审查和访问者的技术来收集数据。二元逻辑回归分析用于确定不遵守的决定因素。结果共纳入411名受试者（137例，274名对照）。他们中大多数是男性。接受抗逆转录病毒治疗持续2年以上[AOR？=？7，95％CI（2.2，22.6）]，不良反应史[AOR？=？6.9，95％CI（1.4，32.9）]，药物使用[与父母同住[AORα= α5.3，95％CI（1.4，20.0）]，与父母同住[AORα= α3.4，95％CI（1.2，10.3）]，有抑郁症状[AORα= α3.3，95％CI（ 1.4，7.5）] ,? 3 分化群4计数[AOR？=？3.2，95％CI（1.8，5.8）]和低饮食多样性[AOR？=？2，95％CI（1.1， 3.7）]被发现是不坚持抗逆转录病毒药物的重要决定因素。结论程序，社会和个人相关因素显示出与不坚持抗逆转录病毒疗法相关的统计学显着性。在这项研究中，建议通过发展个体的自我效能和治疗相关威胁以改善抗逆转录病毒疗法的依从性来管理生活方式。

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