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Determinants of non-adherence to antiretroviral therapy in adult hospitalized patients, Northwest Ethiopia

机译：西北埃塞俄比亚成人住院患者不坚持抗逆转录病毒疗法的决定因素

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Aim: The aim of this study was to assess the rate of antiretroviral therapy (ART) adherence and to identify any determinants among adult patients.Methods: A cross-sectional study was conducted on 351 ART patients in the ART clinic of the University of Gondar referral hospital. Data were collected by a pretested interviewer-administered structured questionnaire from May to June 2014. Multivariate logistic regression was used to determine factors significantly associated with adherence.Results: Of 351 study subjects, women were more predominant than men (64.4% versus 35.6%). Three hundred and forty (96.9%) patients agreed and strongly agreed that the use of ART is essential in their life, and approximately 327 (93.2%) disclosed their sero-status to family. Seventy-nine (22.5%) participants were active substance users. The level of adherence was 284 (80.9%). Three hundred forty-one (97.2%) respondents had good or fair adherence. Among the reasons for missing doses were forgetfulness (29 [43.3%]), missing appointments (14 [20.9%]), running out of medicine (9 [13.4%]), depression, anger, or hopelessness (4 [6.0%]), side effects of the medicine used (2 [3.0%]), and nonbelief in the ART (2 [3.0%]). The variables found significantly associated with non-adherence were age (P-value 0.017), employment (P-value 0.02), HIV disclosure (P-value 0.04), and comfortability to take ART in the presence of others (P-value 0.02).Conclusion: From this study, it was determined that forgetfulness (43.3%) was the most common reason for missing doses. Also, employment and acceptance in using ART in the presence of others are significant issues observed for non-adherence. Hence, the ART counselor needs to place more emphasis on the provision and use of memory aids.
机译：目的：本研究旨在评估抗逆转录病毒疗法（ART）的依从率，并确定成人患者中的任何决定因素。方法：在Gondar大学的ART诊所对351名ART患者进行了横断面研究转诊医院。数据由预先测试的访调员管理的结构化问卷从2014年5月至2014年6月收集。使用多元逻辑回归分析确定与依从性显着相关的因素。结果：在351个研究对象中，女性比男性更占优势（64.4％比35.6％） 。三百四十（96.9％）名患者同意并强烈同意使用抗病毒药物是他们一生中必不可少的，大约327名患者（93.2％）向家人披露了他们的血清状况。七十九（22.5％）名参与者是活性物质使用者。依从性水平为284（80.9％）。 341位受访者（97.2％）拥有良好或中等的依从性。遗失剂量的原因包括健忘（29 [43.3％]），失约（14 [20.9％]），药物用尽（9 [13.4％]），抑郁，愤怒或绝望（4 [6.0％]） ），使用药物的副作用（2 [3.0％]）和不相信抗逆转录病毒疗法（2 [3.0％]）。发现与不依从性显着相关的变量是年龄（P值0.017），就业（P值0.02），HIV暴露（P值0.04）以及在其他人存在的情况下接受抗病毒治疗的舒适性（P值0.02）。 ）结论：从这项研究中，可以确定健忘（43.3％）是缺少剂量的最常见原因。而且，在存在其他人的情况下使用抗逆转录病毒疗法的就业和接受是观察到的不遵守的重大问题。因此，ART咨询师需要更加重视记忆辅助工具的提供和使用。

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