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首页> 外文期刊>American Journal of Analytical Chemistry >Qualitative Determination of Photodegradation Products of Progesterone and Testosterone in Aqueous Solution
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Qualitative Determination of Photodegradation Products of Progesterone and Testosterone in Aqueous Solution

机译：定性测定水溶液中孕酮和睾酮的光降解产物

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摘要

Direct photochemical degradations of progesterone (PR) and testosterone (TR), two naturally produced hormones, have been conducted in non-buffered aqueous solution (pH ranging between 5.5 and 6.0). The irradiation experiments were carried out in a batch reactor upon monochromatic (254 nm) and polychromatic (λ > 290 nm) at 25°C. GLC/MS and LC/UV-DAD/MS analyses were performed to investigate phototransformation products after a solid phase extraction (SPE) step for analytes concentration. For each compound several by-products have been identified and are the same ones under both irradiation conditions. Because of the presence of the same chromophore (α, β-unsaturated group) absorbing UV radiations in both hormones, the majority of chromatographic peaks correspond to by-products formed according to identical mechanisms involving isomerization, enolization, oxidation and hydration to lead to the generation of lumiketone, cyclopentenone, spiro-hydration, oxidation and hydroxylation photoproducts.
机译：在非缓冲水溶液（pH值在5.5到6.0之间）中进行了两种天然产生的激素，孕酮（PR）和睾丸激素（TR）的直接光化学降解。辐射实验是在25°C下在单色（254 nm）和多色（λ> 290 nm）上在间歇反应器中进行的。进行GLC / MS和LC / UV-DAD / MS分析以研究固相萃取（SPE）步骤后分析物浓度的光转化产物。对于每种化合物，已经鉴定了几种副产物，并且在两种照射条件下都是相同的。由于两种激素中都存在吸收紫外线辐射的相同生色团（α，β-不饱和基团），因此大多数色谱峰对应于根据异构化，烯醇化，氧化和水合作用的相同机理形成的副产物，从而导致生成卢甲酮，环戊烯酮，螺合水合，氧化和羟基化光产物。

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