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首页> 外文期刊>American Journal of Drug Discovery and Development >In vitro Antimicrobial Activities of Some Egyptian Plants? Essential Oils with Medicinal Applications
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In vitro Antimicrobial Activities of Some Egyptian Plants? Essential Oils with Medicinal Applications

机译：一些埃及植物的体外抗菌活性？药用精油

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The resistance of microorganisms issue to conventional antibiotics has necessitated the search for efficient and cost effective ways for treating infectious diseases. Plant essential oils are potential sources of novel antimicrobial compounds. In addition, the antimicrobial susceptibility testing provides an information aids in selecting and developing the appropriate antimicrobial agent. In the current study, the chemical compositions of the essential oils of Nigella sativa, Menthe piperita and Pelargonium graveolens (Geranium oil) collected in Egypt were characterized by GC-. In addition, the in vitro antimicrobial activity of these essential oils were tested, using agar diffusion method, against different eleven pathogenic microbial species including three Gram-positive, six Gram-negative and two fungi; a yeast like Candida albicans and a filamentous like Aspergillus niger. Inhibition zones showed that the essential oils of the two plants were active against all Gram-positive studied bacteria and fungi. The susceptibility of the strains changed with the dilution of essential oils in DMSO. The pure essential oils showed the most wide inhibition zones and they were very effective compared to standard drugs ciprofloxacin and/or nystatin. However, the activity against Gram-negative bacteria varied. Thus, this study indicates that the essential oils of Nigella sativa, Menthe piperita and Pelargonium graveolens have antimicrobial activity against different species of human pathogenic microorganisms and research should continue to examine the activity in experimental animals.
机译：微生物对常规抗生素的抗药性需要寻找治疗感染性疾病的有效和成本有效的方法。植物精油是新型抗菌化合物的潜在来源。此外，抗菌药敏试验为选择和开发合适的抗菌药提供了信息帮助。在当前的研究中，通过GC-鉴定了在埃及收集的Nigella sativa，Menthe piperita和Pelargoniumgravolens（天竺葵油）的香精油的化学成分。此外，使用琼脂扩散法测试了这些精油的体外抗微生物活性，这些微生物对11种病原微生物种类包括三种革兰氏阳性菌，六种革兰氏阴性菌和两种真菌。像白色念珠菌一样的酵母和像黑曲霉一样的丝状酵母。抑制区显示，两种植物的精油对所有革兰氏阳性研究的细菌和真菌均具有活性。菌株的敏感性随着在DMSO中稀释精油而改变。纯精油显示出最宽的抑制范围，与标准药物环丙沙星和/或制霉菌素相比，它们非常有效。但是，针对革兰氏阴性细菌的活性各不相同。因此，这项研究表明，Nigella sativa，Menthe piperita和Pelargoniumgraveolens的香精油对不同种类的人类致病微生物具有抗菌活性，应继续研究实验动物的活性。

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