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首页> 外文期刊>Allergology international: official journal of the Japanese Society of Allergology >Evaluating the efficacy of epinastine ophthalmic solution using a conjunctivitis allergen challenge model in patients with birch pollen allergic conjunctivitis
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Evaluating the efficacy of epinastine ophthalmic solution using a conjunctivitis allergen challenge model in patients with birch pollen allergic conjunctivitis

机译：结膜炎变应原激发模型评估桦木眼药水在桦树花粉变应性结膜炎患者中的疗效

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Background The efficacy of epinastine 0.05% ophthalmic solution for pollen allergic conjunctivitis has already been shown in a conjunctival allergen challenge (CAC) test using cedar pollen as a challenge. The present study investigated the efficacy of this solution against birch pollen conjunctivitis in a CAC test. Methods Ten adult subjects (eight males and two females) with asymptomatic birch pollen conjunctivitis were enrolled in this study. The average age of the subjects was 41.1 years. This study was conducted during a period without birch pollen dispersion. In each subject, the epinastine 0.05% ophthalmic solution was instilled in one eye, and an artificial tear fluid was instilled in the fellow eye in a double-blind manner. Five minutes or 4?h after the drug instillation, both eyes were challenged with an optimal concentration of birch pollen, and ocular itching and conjunctival hyperemia were then graded. Tears were collected before the drug instillation and 20?min after the pollen challenge, and the histamine level was measured. Results The ocular itching scores and palpebral conjunctival hyperemia scores of the epinastine-treated eyes were significantly lower than those of the contralateral control eyes when the eyes were pretreated with the drug 4?h before the CAC. There was a significant correlation between the tear histamine level and mean ocular itching score of three time points (3, 5 and 10?min) following the CAC in the control eyes but not the epinastine-treated eyes. Conclusions Epinastine is effective in suppressing ocular itching and conjunctival hyperemia in birch pollen conjunctivitis.
机译：背景技术在以雪松花粉为挑战的结膜变应原挑战（CAC）测试中，已经显示了鼻咽癌0.05％滴眼液对花粉过敏性结膜炎的疗效。本研究在CAC测试中研究了该溶液对桦树花粉结膜炎的功效。方法纳入10例无症状桦木花粉结膜炎的成人受试者（男8例，女2例）。受试者的平均年龄为41.1岁。这项研究是在没有桦树花粉分散的时期进行的。在每位受试者中，将一只眼药水0.05％的淫羊tine碱滴入一只眼睛，并以双盲方式向另一只眼睛滴加人工泪液。滴注药物后5分钟或4？h，用最佳浓度的桦木花粉攻击两只眼睛，然后对眼睛瘙痒和结膜充血进行分级。滴注药物前和花粉刺激后20分钟收集眼泪，并测量组胺水平。结果当在CAC前4小时用药物预处理时，经鼻上结石治疗的眼睛的眼睛瘙痒评分和睑结膜充血评分显着低于对侧对照眼。在对照组眼中，但在经鼻上碱治疗的眼睛中，CAC后三个时间点（3、5和10？min）的泪液组胺水平与平均眼瘙痒评分之间存在显着相关性。结论Epinastine可有效抑制桦树花粉结膜炎的眼痒和结膜充血。

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