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首页> 外文期刊>American Journal of Life Sciences >In vitro studies on antioxidant, hypolipidemic and cytotoxic potential of Parmelia perlata
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In vitro studies on antioxidant, hypolipidemic and cytotoxic potential of Parmelia perlata

机译：梅花蜜的抗氧化，降血脂和细胞毒性潜力的体外研究

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摘要

New drug preparations of natural origin are in need due to the numerous side effects and resistance development through the continuous and uncontrolled use of synthetic drugs. Lichens are reported to have manifold biological activities and in this study, antioxidant, hypolipidemic and cytotoxic potential of Parmelia perlata were assessed. Methanolic extract of P. perlata was prepared and used in DPPH assay, total phenolic content and total antioxidant potential assays. In vitro anti-cholesterol and cytotoxic assay using HCT 116 cell lines were performed. The results revealed that P. perlata contain high phenolic contents and antioxidant potential. Simvastatin was used as standard drug and the extracts demonstrated 48% anti-cholesterol activity. MTT assay using colon cancer cell lines (HCT 116) produced dose dependent cytotoxic effect with an IC50 value of 202.1 μg ml~(-1).
机译：由于合成药物的持续和不受控制的使用会产生许多副作用和耐药性，因此需要天然来源的新药物制剂。据报道，地衣具有多种生物活性，在这项研究中，对百日草的抗氧化剂，降血脂和细胞毒性潜力进行了评估。制备了P. perlata的甲醇提取物，并将其用于DPPH测定，总酚含量和总抗氧化剂电位测定。使用HCT 116细胞系进行了体外抗胆固醇和细胞毒性测定。结果表明，P。perlata含有较高的酚含量和抗氧化能力。辛伐他汀用作标准药物，提取物具有48％的抗胆固醇活性。使用结肠癌细胞系（HCT 116）的MTT分析产生剂量依赖性的细胞毒性作用，IC50值为202.1μgml〜（-1）。

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