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首页> 外文期刊>Allergy & Rhinology >The study of a possible correlation between serum levels of interleukin 17 and clinical severity in patients with allergic rhinitis
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The study of a possible correlation between serum levels of interleukin 17 and clinical severity in patients with allergic rhinitis

机译：变应性鼻炎患者血清白细胞介素17水平与临床严重程度之间可能相关性的研究

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Introduction: Allergic rhinitis (AR) is one of the most common allergic diseases, which affects ～20% of the world's population. T-helper (Th) type 2 cells produce interleukin (IL) 4 and IL-13, and mediate allergic responses, and these cytokines have been extensively studied as key players in the atopic airway diseases. However, the involvement of Th17 cells and IL-17 in AR has not been clearly examined. Aim: To reevaluate AR clinical severity with serum IL-17, whether IL-17 affects the disease alone or in contribution with the atopic predisposition. Patients and Methods: During an 18-month period, 39 individuals were divided into three groups: A, (13 control), B (13 with mild-to-moderate AR), and C (13 with severe AR). Both group B and group C patients (26) were subjected to clinical examination and allergy skin testing, and to measurement of both total serum immunoglobulin E (IgE) and IL-17 levels. Eleven patients with AR then were exposed to 6 months of cluster immunotherapy, whereas the rest of the patients were not exposed. Results: Revealed a significant elevation of serum IL-17 levels with an associated increase in serum IgE in the patients with AR compared with controls and revealed that the serum levels of both total serum IgE and IL-17 decreased significantly after cluster immunotherapy. Conclusion: These preliminary results added new data about the use of injective immunotherapy as well as reported on the use of sublingual immunotherapy.
机译：简介：过敏性鼻炎（AR）是最常见的过敏性疾病之一，影响约20％的世界人口。 T型辅助（Th）2型细胞产生白介素（IL）4和IL-13，并介导过敏反应，这些细胞因子已被广泛研究为特应性气道疾病的关键因素。但是，尚未明确检查Th17细胞和IL-17是否参与AR。目的：为了重新评估血清IL-17引起的AR临床严重性，IL-17是单独影响疾病还是与特应性疾病有关。患者和方法：在18个月的时间里，将39例患者分为三组：A，（13例对照），B（13例轻至中度AR）和C（13例重度AR）。 B组和C组患者（26）均接受了临床检查和过敏性皮肤测试，并同时测量了血清总免疫球蛋白E（IgE）和IL-17的水平。然后有11名AR患者接受了6个月的整群免疫治疗，而其余患者则没有接受。结果：与对照组相比，AR患者的血清IL-17水平显着升高，同时血清IgE升高，并且在整群免疫治疗后血清总IgE和IL-17均显着下降。结论：这些初步结果为注射免疫疗法的使用以及舌下免疫疗法的使用提供了新数据。

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