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首页> 外文期刊>Aging cell. >B-cell diversity decreases in old age and is correlated with poor health status
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B-cell diversity decreases in old age and is correlated with poor health status

机译：B细胞多样性随着年龄的增长而下降，并且与健康状况不佳相关

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Older people suffer from a decline in immune system, which affects their ability to respond to infections and to raise efficient responses to vaccines. Effective and specific antibodies in responses from older individuals are decreased in favour of non-specific antibody production. We investigated the B-cell repertoire in DNA samples from peripheral blood of individuals aged 86–94 years, and a control group aged 19–54 years, using spectratype analysis of the IGHV complementarity determining region (CDR)3. We found that a proportion of older individuals had a dramatic collapse in their B-cell repertoire diversity. Sequencing of polymerase chain reaction products from a selection of samples indicated that this loss of diversity was characterized by clonal expansions of B cells in vivo. Statistical analysis of the spectratypes enabled objective comparisons and showed that loss of diversity correlated very strongly with the general health status of the individuals; a distorted spectratype can be used to predict frailty. Correlations with survival and vitamin B12 status were also seen. We conclude that B-cell diversity can decrease dramatically with age and may have important implications for the immune health of older people. B-cell immune frailty is also a marker of general frailty.
机译：老年人的免疫系统下降，这影响了他们对感染的反应能力以及对疫苗的有效反应能力。降低来自老年人的反应中的有效和特异性抗体，有利于非特异性抗体的产生。我们使用IGHV互补决定区（CDR）3的光谱类型分析调查了86-94岁个体和19-54岁对照组外周血DNA样本中的B细胞组成。我们发现，一部分老年人的B细胞库多样性急剧下降。从一些样品中对聚合酶链反应产物进行测序表明，这种多样性丧失的特征是体内B细胞的克隆扩增。光谱类型的统计分析可以进行客观比较，并显示多样性的丧失与个体的总体健康状况密切相关;扭曲的光谱类型可用于预测脆弱性。还观察到与生存和维生素B12状态的相关性。我们得出的结论是，B细胞多样性会随着年龄的增长而急剧下降，并可能对老年人的免疫健康产生重要影响。 B细胞免疫脆弱也是一般脆弱的标志。

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