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首页> 外文期刊>Alexandria Journal of Medicine >Efficacy of Allium sativum (garlic) against experimental cryptosporidiosis
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Efficacy of Allium sativum (garlic) against experimental cryptosporidiosis

机译：大蒜（大蒜）对实验性隐孢子虫病的功效

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Background Due to increasing problems of inadequate and unreliable medical treatments for Cryptosporidium enteritis, alternative therapies are being sought. Objective The current study was designed to evaluate the prophylactic and therapeutic efficacy of Allium sativum (garlic) against Cryptosporidium infection in experimentally infected immunocompetent and immunosuppressed mice. Methods Forty eight male Swiss albino mice were divided equally into control and experimental groups. Each group was further subdivided into four equal subgroups; two immunosuppressed and two immunocompetent. Cryptosporidial oocysts were isolated from human stools, and were used to infect the mice. The experimental subgroups received garlic orally two days before infection or one day following infection, and continued daily till the end of the study. Two weeks following garlic administration, mice stools were examined for counting the cryptosporidial oocysts, then the animals were sacrificed; their small intestines were processed and were examined for detection of the pathological lesions and for counting of the parasites. Also, myeloperoxidase (MPO) activity was measured in jejunal sections. Results The results showed that the infected immunosuppressed subgroups of mice; showed a statistically significant increase in the number of cryptosporidial oocysts in stool and ileal sections, as well as an increase in the MPO activity when compared to the corresponding immunocompetent subgroups. Garlic successfully eradicated the Cryptosporidium oocysts from stool and intestinal sections of the infected immunocompetent subgroup of mice receiving garlic two days before the infection. Besides, the oocysts were significantly reduced in all other infected experimental subgroups in comparison to the corresponding infected control subgroups. The intestinal sections of all subgroups received garlic before or after the infection, revealed a more or less normal architecture. Reduction in the level of MPO activity was also detected in all experimental subgroups. Conclusion Our findings suggest that garlic is a convenient prophylactic and a promising therapeutic agent for cryptosporidial infection.
机译：背景技术由于隐孢子虫性肠炎的药物治疗不充分和不可靠的问题日益严重，正在寻找替代疗法。目的本研究旨在评估大蒜（大蒜）对经实验感染的具有免疫功能和免疫抑制的小鼠的隐孢子虫感染的预防和治疗效果。方法48只瑞士白化病雄性小鼠平均分为对照组和实验组。每个组又细分为四个相等的子组。两种免疫抑制和两种免疫能力。从人粪便中分离出隐孢子虫卵囊，并用于感染小鼠。实验组在感染前两天或感染后一天口服大蒜，每天持续进行直至研究结束。大蒜施用后两周，检查小鼠粪便以计数隐孢子虫卵囊，然后处死动物。对其小肠进行处理，检查其病理病变的检测和寄生虫计数。而且，在空肠切片中测量了髓过氧化物酶（MPO）活性。结果结果表明，感染的小鼠免疫抑制了亚组。与相应的具有免疫能力的亚组相比，粪便和回肠部分的隐孢子虫卵囊数量增加了统计学显着，MPO活性也增加了。大蒜在感染前两天成功地从接受大蒜免疫的受感染小鼠的粪便和肠段中成功清除了隐孢子虫卵囊。此外，与相应的感染对照亚组相比，所有其他感染的实验亚组的卵囊明显减少。所有亚组的肠段在感染之前或之后都接受大蒜，显示出或多或少的正常结构。在所有实验亚组中还检测到MPO活性水平降低。结论我们的发现表明，大蒜是隐孢子虫感染的便捷预防方法和有希望的治疗剂。

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