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首页> 外文期刊>Current Applied Polymer Science >Polymer-based Nanodevices for Effective Antimicrobial Therapy: Synthetic Strategies and Applications | Bentham Science
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Polymer-based Nanodevices for Effective Antimicrobial Therapy: Synthetic Strategies and Applications | Bentham Science

机译：基于聚合物的纳米器件可有效进行抗菌治疗：合成策略和应用边沁科学

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Background: Despite the great development of drug-based therapy in all areas of medicine,microbial infections remain nowadays one of the most complicated issues in human healthcare. In orderto improve drugs efficiency, many nanocarriers have been developed, aiming to an increased therapeuticefficacy based on targeted drug delivery at infection sites, reduced drug-resistance by microbial organismsand increased therapeutic index. This leads to reduced side effects and improved patient compliancethanks to the decreased frequency of administration.Objective: Many materials can be used to prepare nanocarriers, such as lipids, polymers or inorganicparticles. Among these, polymers are of great interest including a wide range of materials with the possibilityof modification of their physical-chemical properties.Method: Polymeric nanocarriers are here classified as nanogels, dendrimers, polymersomes and polymericmicelles and a general discussion about synthetic strategies is given. Strategy is, indeed, fundamentalto control the dimensions of the system, ranging between 10 to 1000 nm, and it is set up also basingon drug loading procedure, incorporating, encapsulating or conjugating the antimicrobial drug.Conclusion: In addition, the main mechanisms of interaction of polymeric nanocarriers with microbialorganisms are described and, eventually, peculiar advantages and drawbacks of each class of these systemsare explained.
机译：背景：尽管基于药物的疗法在医学的各个领域都取得了长足发展，但微生物感染如今仍是人类医疗保健中最复杂的问题之一。为了提高药物效率，已经开发了许多纳米载体，旨在基于在感染部位的靶向药物递送，降低的微生物对药物的耐药性和提高的治疗指数来提高治疗效果。由于减少了给药频率，因此减少了副作用并提高了患者的依从性。目的：许多材料可用于制备纳米载体，例如脂质，聚合物或无机颗粒。在这些聚合物中，聚合物受到广泛关注，其中包括范围广泛的材料，其物理化学性质可能会发生改变。方法：本文将聚合物纳米载体分为纳米凝胶，树枝状聚合物，聚合物囊泡和聚合物胶束，并对合成策略进行了一般性讨论。实际上，策略是控制系统尺寸的根本方法，范围在10至1000 nm之间，并且它还建立了基础的药物加载程序，包括，封装或缀合抗菌药物。结论：此外，相互作用的主要机制描述了具有微生物的聚合物纳米载体，并最终解释了每种类型的这些系统的特殊优点和缺点。

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