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首页> 外文期刊>Current Applied Polymer Science >Design, Development and Optimization of Glibenclamide Sustained Release Matrix Tablet by Using Natural Polymers | Bentham Science
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Design, Development and Optimization of Glibenclamide Sustained Release Matrix Tablet by Using Natural Polymers | Bentham Science

机译：天然聚合物格列本脲缓释基质片剂的设计，开发与优化边沁科学

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Background: Tablets being the conventional dosage forms can be modified for providingthe desired therapeutic effect to the patients. The network of matrix in the tablet allows the drug releaseto be slowed down considerably.Objective: The prime objective of the study was to formulate sustained release glibenclamide matrixtablets using locust bean gum and karaya gum as a matrix polymer.Methods: Tablets were formulated by optimization using 32 factorial designs by direct compressionmethod using different drug: polymer concentrations. The dependent variables selected were % cumulativedrug release (Y1) and % drug content (Y2). The independent variables are the amount of locustbean gum (X1) and karayagum (X2). Drug-polymer compatibility studies were confirmed byFTIR and DSC. The pre-compression properties of powder were assessed indicating a good flowproperty. The evaluation results of the tablets were found to be within the Indian Pharmacopoeiallimit. In this work, the effect of diluents type and polymer type was studied on the drug release withits increase in concentration.Results: All the formulations showed retarded drug release as the concentration of the polymer wasincreased. Formulation F8 was selected as the best-optimized formulation with about 100.56% drugrelease within 12 h. Release kinetics was carried out and it was found to be zero-order release andfrom assay, drug content was found to be in limits.Conclusion: ANOVA analysis indicated that the studied variables affected the response variablessignificantly. The optimized formulation was stable. Hence, it is concluded that the Glibenclamidesustained release matrix tablet containing natural polymers were successfully formulated by using 32factorial design.
机译：背景：可以修饰作为常规剂型的片剂以为患者提供所需的治疗效果。片剂中的基质网络使药物的释放速度大大降低。目的：本研究的主要目的是使用刺槐豆胶和卡拉叶胶作为基质聚合物制备缓释格列本脲基质片剂。方法：通过优化配方制备片剂通过32种阶乘设计，通过直接压缩方法使用不同的药物：聚合物浓度。选择的因变量是累积药物释放百分比（Y1）和药物含量百分比（Y2）。自变量是刺槐豆胶（X1）和卡拉雅木（X2）的量。 FTIR和DSC证实了药物-聚合物相容性研究。评估粉末的预压缩性能，表明其良好的流动性。片剂的评估结果被发现在印度药典范围内。本研究研究了稀释剂类型和聚合物类型对药物释放的影响，并随着浓度的增加而增加。结果：随着聚合物浓度的增加，所有制剂均显示出药物释放的延迟。选择配方F8作为最佳优化的配方，在12小时内释放约100.56％的药物。进行了释放动力学研究，发现其为零级释放，从试验中发现药物含量处于极限。结论：方差分析表明所研究的变量对响应变量有显着影响。优化的配方是稳定的。因此，可以得出结论，使用32因子设计成功地制备了含有天然聚合物的格列本脲缓释基质片剂。

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