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首页> 外文期刊>American Journal of Epidemiology and Infectious Disease >Rotavirus Infection in a Secondary Hospital, Laboratory Diagnosis and Impact of Immunization on Pediatric Hospitalization Saudi Arabia
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Rotavirus Infection in a Secondary Hospital, Laboratory Diagnosis and Impact of Immunization on Pediatric Hospitalization Saudi Arabia

机译：二级医院轮状病毒感染，实验室诊断和免疫接种对小儿住院的影响沙特阿拉伯

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Rotavirus is the most common cause of gastroenteritis (diarrhea) disease among infants and young children, Rotavirus is usually an easily managed disease of childhood, infections are most common during the winter months from November to May. However, infection with rotavirus can occur anytime of the year, There are currently 2 FDA-approved rotavirus vaccines to protect against rotavirus gastroenteritis (RotaTeq and Rotarix). These vaccines are indicated in infants aged 6-32 weeks (RotaTeq) and those aged 6-24 weeks (Rotarix). OBJECTIVES: Conduct viral testing on stool samples from diarrhea patients to determine ROTA viruses that as a cause of diarrhea, and effectiveness of vaccine. STUDY DESIGN: A retrospective cross section study was conducted using stool samples collected from children with diarrhea (n=285) between January 2015 and December 2016. Samples were tested for rotavirus, were determined by Enzyme immunoassay, Latex agglutination. Result: two hundred eighty five stool samples from children with acute diarrhea attend to our hospital in 2015 and 2016 were examined by commercial latex and immunoenzymatic assays for the diagnosis of rotavirus infection in laboratories. for comparison, sensitivity and specificity for the latex and ELISA assays ELISA and Latex Test specificity 98.5 % Latex sensitivity 88 % to ELISA. Around 16% of our study population with diarrhea disease were diagnosed as ROTA (45/285) AMONGE THEM 89% 40/54were previous vaccinated with RTOTARIX CONCLUSION Rotavirus is an infection that causes diarrhea. It's the most common cause of diarrhea in infants and children less than 5 years old worldwide, according to the Centers for CDC Rotavirus vaccines are very effective at preventing rotavirus disease, However in our study we found most of patients were vaccinated according to national vaccination program still had a disease and the vaccination only modified disease course decrease days of hospitalization for further expanded and comparative study for types of vaccination.
机译：轮状病毒是婴幼儿胃肠炎（腹泻）疾病的最常见病因，轮状病毒通常是一种易于控制的儿童疾病，在11月至5月的冬季，感染最为普遍。但是，轮状病毒感染可能在一年中的任何时间发生。目前有2种FDA批准的轮状病毒疫苗可以预防轮状病毒胃肠炎（RotaTeq和Rotarix）。这些疫苗适用于6至32周龄的婴儿（RotaTeq）和6至24周龄的婴儿（Rotarix）。目的：对腹泻患者的粪便样本进行病毒测试，以确定引起腹泻的ROTA病毒以及疫苗的有效性。研究设计：回顾性横断面研究使用2015年1月至2016年12月从腹泻儿童（n = 285）收集的粪便样本进行。通过酶免疫测定，乳胶凝集法测定样本的轮状病毒。结果：2015年和2016年在我院就诊的急性腹泻患儿的285份粪便样本通过商业乳胶和免疫酶联免疫吸附试验进行了检测，以在实验室中诊断出轮状病毒感染。为了进行比较，乳胶和ELISA分析的灵敏度和特异性ELISA和Latex测试特异性98.5％乳胶对ELISA的灵敏度为88％。在我们的腹泻病研究人群中，约有16％被诊断为ROTA（45/285）。他们当中89％40/54曾接受过RTOTARIX疫苗接种结论轮状病毒是一种引起腹泻的感染。根据CDC中心的说法，它是全世界5岁以下婴幼儿腹泻的最常见原因，轮状病毒疫苗在预防轮状病毒疾病方面非常有效，但是在我们的研究中，我们发现大多数患者都是根据国家疫苗接种计划接种的仍然患有某种疾病，并且仅通过改变病程的疫苗接种减少了住院天数，以便进一步扩大和比较疫苗接种类型的研究。

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