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Aging and exercise effects on motor learning and spatial memory

机译：衰老和运动对运动学习和空间记忆的影响

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The aim of this experiment was to determine whether low impact forced exercise improved learning and memory in middle aged and older mice. The effects of 12 weeks of low impact, forced running on motor learning and spatial memory were compared in 32 C57BL/6 mice in three age groups with a mean age of 13, 17, and 25 months. Motor learning was assessed with the rotorod, and spatial memory was assessed with the Morris water maze (MWM). Mice were randomly assigned to the forced exercise or sedentary control group and were treated for 60 min/day (2 30-min sessions) for 12 weeks. Significant age differences were observed on the rotorod (15 and 25 RPM) with the 13-month-old mice outperforming 17- and 25-month-old mice. Age differences were also observed on the MWM, with 25-month mice impaired in latency to escape and distance covered. The effect of exercise on rotorod performance did not attain statistical significance, but the mean performance of runners was higher than that of controls. Exercise improved spatial memory retention in the MWM and led to significant improvement in acquisition distance. Low impact forced exercise did not have strong effects on motor learning as assessed by the rotorod. However, low impact forced exercise did improve retention of spatial memory in 13-month-old mice. Slight improvements in spatial memory were seen in the oldest runners, though this experiment suggested that the beneficial effect of exercise and plasticity in memory was generally limited to 13-month-old middle aged mice, with significant age-related differences in motor and spatial learning occurring in the 4- month period between 13 and 17 months.
机译：该实验的目的是确定低影响的强迫运动是否可以改善中老年小鼠的学习和记忆能力。在三个年龄组的平均年龄分别为13、17和25个月的32只C57BL / 6小鼠中比较了12周的低冲击力，强迫跑步对运动学习和空间记忆的影响。用旋翼机评估运动学习，并用莫里斯水迷宫（MWM）评估空间记忆。将小鼠随机分配至强迫运动或久坐对照组，并以60分钟/天（2次30分钟的疗程）治疗12周。在13个月大的老鼠表现优于17和25个月大的老鼠的旋翼机上观察到明显的年龄差异（15和25 RPM）。在MWM上还观察到了年龄差异，其中25个月的小鼠逃跑潜伏期和距离覆盖受损。锻炼对旋翼机性能的影响没有统计学意义，但跑步者的平均表现高于对照组。锻炼改善了MWM中的空间记忆保持力，并显着改善了采集距离。如旋翼机所评估的那样，低冲击力的强迫运动对运动学习没有强烈的影响。但是，低影响的强制运动确实可以改善13个月大小鼠的空间记忆保持力。在最年长的跑步者中，空间记忆有所改善，尽管该实验表明，运动和记忆可塑性的有益作用通常仅限于13个月大的中年小鼠，运动和空间学习方面与年龄相关的差异显着发生在13到17个月之间的4个月内。

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