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首页> 外文期刊>Animal Reproduction >Effect of aflatoxin B 1 on blood serum oestradiol-17β and progesterone concentrations during the luteal phase and the synchronized oestrus of goats
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Effect of aflatoxin B 1 on blood serum oestradiol-17β and progesterone concentrations during the luteal phase and the synchronized oestrus of goats

机译：黄曲霉毒素B 1对黄体期和同步发情期山羊血清雌二醇17β和孕酮浓度的影响

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摘要

The effect of prolonged aflatoxin B 1 (AFB 1 ) administration on blood serum oestradiol-17β and progesterone concentrations in goats during the luteal phase and the synchronized oestrus was investigated. Thirty-six Greek indigenous primiparous goats were used, during the oestrus period; 12 goats received, per os, 50 μg (treated group T50) and 12 goats received 100 μg (treated group T100) AFB 1 /day/head, respectively, for approximately 1.5 month, while 12 goats served as controls (C). On day 36 of the experiment, each goat was injected, i.m, 0.5 ml prostaglandin F 2α (PGF 2α ). Blood samples were collected from each goat twice a week, before PGF 2α injection, as well as every 4 hours from the onset to the end of the synchronized oestrus. Oestradiol-17β and progesterone concentrations in blood serum were determined using radioimmunoassay. During the whole luteal(s) phase(s), linear regression analysis revealed a significant negative dependence (P 0.05). In conclusion, prolonged AFB 1 administration at doses of 100 or even of 50 μg/day/head changes the hormonal pattern in blood during the luteal phase and the synchronized oestrus of goats, being in oestrus period.
机译：研究了在黄体期和同步发情期中，长期服用黄曲霉毒素B 1（AFB 1）对山羊血清oestradiol-17β和孕酮浓度的影响。在发情期使用了三十六只希腊土著初产山羊。每天口服12头山羊50μg（治疗组T50）和12头山羊100 mg（治疗组T100）AFB 1 /天/头，持续约1.5个月，而12头山羊作为对照（C）。在实验的第36天，每只山羊被注射0.5 ml前列腺素F2α（PGF2α）。在注射PGF2α之前，每周两次从每只山羊采集血样，从开始发情到发情末期每4小时采集一次。使用放射免疫测定法测定血清中的雌二醇-17β和孕酮浓度。在整个黄体阶段，线性回归分析显示出显着的负相关性（P 0.05）。总之，以100甚至50μg/天/头的剂量长期施用AFB 1会改变黄体期和处于发情期的山羊同步发情期间血液中的激素模式。

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