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首页> 外文期刊>Czech Journal of Animal Science >Effect of prolonged aflatoxin B-1 administration on blood serum oestradiol-17 beta and progesterone concentrations of goats during the anoestrus period
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Effect of prolonged aflatoxin B-1 administration on blood serum oestradiol-17 beta and progesterone concentrations of goats during the anoestrus period

机译：黄曲霉毒素B-1延长对缺铁期山羊血清oestradiol-17β和孕酮浓度的影响

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摘要

The effect of prolonged aflatoxin B-1 (AFB(1)) administration on blood serum oestradiol-17 beta and progesterone concentrations in goats during the anoestrus period was investigated. Thirty Greek indigenous goats were used; 10 goats received, per os, 50 mu g (treated group T50) and 10 goats received 100 mu g (treated group T100) AFB(1)/day/head, respectively, for 31 days, while 10 goats served as controls (C). Blood samples were collected from each goat twice a week to determine serum oestradiol-17 beta and progesterone concentrations by radioimmunoassay. Multiple linear regression analysis revealed a significant (P 0.05) positive dependence of blood serum oestradiol-17 beta concentration over group (C = 0, T50 = 50, T100 = 100), in a dose-dependent manner, and a significant (P 0.05) negative dependence over time (0-31 days, from the onset to the end of AFB(1) administration). Linear regression analysis revealed a significant (P 0.05) positive dependence of blood serum progesterone concentration over group (C = 0, T50 = 50, T100 = 100), in a dose-dependent manner. Pearson's correlation coefficient revealed a significant (P 0.05) positive correlation between blood serum oestradiol-17 beta and progesterone concentration, but only in the goats of the control group. In conclusion, the prolonged administration of 100 or even of 50 mu g AFB(1)/day/head during the anoestrus period, increased blood serum oestradiol-17 beta and progesterone concentrations of goats, in a dose-dependent manner, and in the treated groups disturbed the positive correlation between oestradiol-17 beta and progesterone concentration shown in the goats of the control group.
机译：研究了延长黄曲霉毒素B-1（AFB（1））给药对山羊在发情期的血清oestradiol-17β和孕酮浓度的影响。使用了三十只希腊土著山羊。每天口服10头山羊50克（治疗组T50），10头山羊每天100克（治疗组T100）AFB（1）/天/头，持续31天，而10头山羊作为对照（C ）。每周两次从每只山羊采集血样，以通过放射免疫测定法测定血清雌二醇-17β和孕酮浓度。多元线性回归分析显示，血清oestradiol-17 beta浓度与组（C = 0，T50 = 50，T100 = 100）呈显着（P <0.05）正相关，且呈剂量依赖性，而与P（0.05）呈显着正相关（P <0.05）随时间推移（从发病至AFB（1）给药结束至0-31天）的负相关性。线性回归分析显示，血清孕酮浓度与组（C = 0，T50 = 50，T100 = 100）相比有显着（P <0.05）正相关性。皮尔逊相关系数显示，血清雌二醇17β与孕酮浓度之间存在显着正相关（P <0.05），但仅在对照组的山羊中。总之，在花粉期期间长期施用100甚至50μgAFB（1）/天/头，以剂量依赖的方式并以剂量依赖性方式增加了山羊的血清oestradiol-17 beta和孕酮浓度。处理组扰乱了对照组山羊中显示的雌二醇17β与孕酮浓度之间的正相关性。

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