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Intrauterine growth restriction: screening and diagnosis using animal models

机译：宫内生长受限：使用动物模型进行筛查和诊断

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Intrauterine growth restriction (IUGR) is a serious condition of multifactorial origin, mainly caused by maternal malnutrition, multiple gestation associated with nutrient competition, abuse of nocive substances and infections. The diagnosis of such syndrome is complex, as its own manifestations can mask its occurrence, requiring a thorough assessment of body weight and size. Moreover, it is not responsive to any kind of treatment. There is evidence that IUGR may predispose the individual to several pathologies, such as diabetes, hypertension and metabolic syndrome in adulthood, and it has also been linked to thrifty phenotype hypothesis. Thus, a healthy lifestyle is needed to better prevent those pathologies. Given the world high prevalence and importance of IUGR, mainly in developing countries, this review is focused on discussing how different animal models contribute to the biological screening and diagnosis of this condition.
机译：宫内生长受限（IUGR）是多因素起源的严重疾病，主要是由母亲营养不良，与营养竞争相关的多次妊娠，滥用有益物质和感染引起的。这种综合征的诊断很复杂，因为其自身的表现可以掩盖其发生，因此需要对体重和大小进行彻底评估。而且，它对任何类型的治疗均无反应。有证据表明，IUGR可能使个体易患多种疾病，例如成年后的糖尿病，高血压和代谢综合症，并且也与节俭表型假说有关。因此，需要一种健康的生活方式来更好地预防这些疾病。鉴于世界上IUGR的普遍性和重要性，主要是在发展中国家，本综述着重讨论了不同的动物模型如何促进这种疾病的生物学筛查和诊断。

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