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首页> 外文期刊>Annual Research & Review in Biology >Opioid System (?2-endorphin) and Stress Hormones Profiling in Women with Polycystic Ovary Syndrome
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Opioid System (?2-endorphin) and Stress Hormones Profiling in Women with Polycystic Ovary Syndrome

机译：阿片样物质系统（β2-内啡肽）和多囊卵巢综合征女性的应激激素分析

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Aims: In this study, we investigated serumβ-endorphin and its feedback system in women with polycystic ovary syndrome (PCO). Experimental and clinical studies show that there is an over activity of sympathetic nervous system in PCOS. It affects quality of life and can worsen anxiety and depression either due to the features of PCOS or due to the diagnosis of a chronic disease. Study Area and Duration of Study: This study was carried out at Vali-e-Asr Clinic, a Reproductive Health Research Center, affiliated to Tehran University of Medical Sciences between February 2012 and April 2013. Methodology: 77 women with PCO were studied with diagnose criteria and within the age range of 20-40 years without special disease. Stress neurohormones, beta-endorphine and melatonin serum levels were measured in study group and were compared with healthy women as control group. A questionnaire with items related to pieces of information about stress was used for data collection. Stress symptoms were assessed using the Understanding Yourself questionnaire. Statistical analyses were performed using SPSS Ver. 13.0 (SPSS Inc., Chicago, ILL, USA). The data are presented as mean ± SD or as frequency with percentages. A p-value less than 0.05 were considered as statistically significant. Results: Data of serum levels of neurohormones showed, beta endorphin decreased (P<0.001) and adrenaline increased (P<0.001) in women with PCO. Significantly inhibited the opioid system may be one of the main reasons of the hyperactivity in two super systems: HPA and sympathetic nervous system. Conclusion: Earlier reports stated that opioid system decreases sympathetic tone in the brain in normal condition, our results in this study confirm the over activity of sympathetic nervous system which was due to decreasing opioid system activity in women with polycystic ovary syndrom (PCO).
机译：目的：在这项研究中，我们调查了多囊卵巢综合征（PCO）女性的血清β-内啡肽及其反馈系统。实验和临床研究表明，PCOS中交感神经系统活动过度。由于PCOS的特征或由于对慢性疾病的诊断，它会影响生活质量并会使焦虑和抑郁恶化。研究范围和研究持续时间：该研究在德黑兰医科大学附属生殖健康研究中心Vali-e-Asr诊所进行，时间为2012年2月至2013年4月。方法：对77名患有PCO的女性进行了诊断性研究。标准和年龄在20-40岁之间且无特殊疾病。测量研究组的应激神经激素，β-内啡肽和褪黑激素血清水平，并与健康女性作为对照组进行比较。问卷中包含与压力相关信息相关的项目，用于数据收集。使用“了解自己”问卷评估压力症状。统计分析使用SPSS Ver。 13.0（SPSS Inc.，美国伊利诺伊州芝加哥）。数据以平均值±SD或频率（带百分比）表示。小于0.05的p值被认为具有统计学意义。结果：PCO妇女的神经激素血清水平数据显示，β内啡肽降低（P <0.001），肾上腺素升高（P <0.001）。阿片类药物系统的显着抑制可能是两个超级系统：HPA和交感神经系统过度活跃的主要原因之一。结论：较早的报道指出，阿片样物质系统在正常情况下会降低大脑的交感神经张力，我们的研究结果证实了交感神经系统的过度活动是由于多囊卵巢综合征（PCO）妇女的阿片样物质系统活动减少所致。

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