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首页> 外文期刊>Annual Review & Research in Biology >Neuroprotective Properties of NMDA R1 Antagonist (Ketamine) in Cyanide Treated Neurons in vitro
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Neuroprotective Properties of NMDA R1 Antagonist (Ketamine) in Cyanide Treated Neurons in vitro

机译：NMDA R1拮抗剂（氯胺酮）对氰化物处理的神经元的体外神经保护作用

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Aims: This study aims at investigating possible means of reducing cyanide toxicity by blocking NMDA R1 via ketamine (an NMDA R1 antagonist). This is to provide a template for quick arrest of cyanide toxicity in neurons under oxygen deprived condition.Place and Duration of Study: Bingham University, Department of Anatomy, Karu, Nigeria. The duration of the study was100 minutes.Methodology: Freshly harvested cortical tissue blocks were perfused in accessory cerebrospinal fluid (ACSF) containing all the necessary salts and glucose. The cultures were treated with ACSF (Control), ACSF+KCN (potassium cyanide), ACSF+KCN+Ketamine and ACSF+Ketamine for a total duration of 100 minutes at 37oC. Results: The Ketamine had a protective and reversal effects on the tissues both for oxygen deprivation and cyanide toxicity, The cells in tissues treated with ACSF+KCN+Ketamine showed normal appearance of cell body and axonal projections, the cells treated with ACSF+Ketamine showed fewer degenerating cells compared to those treated with cyanide.Conclusion: Ketamine, an NMDA R1 antagonist is neuroprotective against the toxicity of cyanide.
机译：目的：本研究旨在研究通过氯胺酮（NMDA R1拮抗剂）阻断NMDA R1来降低氰化物毒性的可能方法。这为在缺氧条件下快速阻止神经元中氰化物毒性提供了模板。研究的地点和持续时间：宾厄姆大学，解剖学系，尼日利亚卡鲁。研究持续时间为100分钟。方法：将新鲜收获的皮质组织块灌注到含有所有必要盐和葡萄糖的副脑脊液（ACSF）中。将培养物用ACSF（对照），ACSF + KCN（氰化钾），ACSF + KCN +氯胺酮和ACSF +氯胺酮在37℃下处理100分钟。结果：氯胺酮对组织的缺氧和氰化物毒性均具有保护和逆转作用，经ACSF + KCN +氯胺酮处理的组织细胞显示正常的细胞体和轴突突起，经ACSF + Ketamine处理的细胞显示结论：氯胺酮是一种NMDA R1拮抗剂，对氰化物的毒性具有神经保护作用。

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