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首页> 外文期刊>Advances in hematology >Expression of Thymidine Phosphorylase in Lymph Nodes Involved with Mycosis Fungoides and Sézary Syndrome
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Expression of Thymidine Phosphorylase in Lymph Nodes Involved with Mycosis Fungoides and Sézary Syndrome

机译：胸苷磷酸化酶在涉及真菌病和塞萨里氏综合症的淋巴结中的表达

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Thymidine phosphorylase may be overexpressed in both neoplastic cells and tumor stromal cells in a variety of malignancies. Our study explores thymidine phosphorylase expression in lymph nodes (LNs) from patients with mycosis fungoides (MF) or Sézary syndrome (SS). In MF/SS, the LNs may have a pathologic diagnosis of either dermatopathic lymphadenopathy (LN-DL) or involvement by MF/SS (LN-MF). We performed immunohistochemical staining on MF/SS lymph nodes using antibodies to thymidine phosphorylase, CD68, CD21, CD3, and CD4. In both LN-DL and benign nodes, thymidine phosphorylase staining was noted only in macrophages, dendritic cells, and endothelial cells. In LN-MF, thymidine phosphorylase expression was also noted in subsets of intermediate to large neoplastic T cells. Concurrent CD68, CD21, CD3, and CD4 staining supported the above observations. Similar results were noted in the skin and in LN-MF with large cell transformation. Other T-cell lymphomas were also examined (total 7 cases); only enteropathy-type T-cell lymphoma (1 case) showed TP positivity in neoplastic T lymphocytes. We demonstrated that thymidine phosphorylase staining is present in neoplastic T cells in mycosis fungoides. The exact mechanism needs further investigation.
机译：胸腺嘧啶磷酸化酶可能在多种恶性肿瘤的肿瘤细胞和肿瘤基质细胞中均过表达。我们的研究探讨了蕈样真菌病（MF）或塞萨里综合征（SS）患者淋巴结（LNs）中胸苷磷酸化酶的表达。在MF / SS中，LN可能具有皮肤病性淋巴结病（LN-DL）或MF / SS参与（LN-MF）的病理诊断。我们使用针对胸苷磷酸化酶，CD68，CD21，CD3和CD4的抗体对MF / SS淋巴结进行了免疫组织化学染色。在LN-DL和良性淋巴结中，仅在巨噬细胞，树突状细胞和内皮细胞中发现胸苷磷酸化酶染色。在LN-MF中，胸腺嘧啶磷酸化酶的表达也出现在中型至大型肿瘤T细胞的子集中。同时进行的CD68，CD21，CD3和CD4染色支持上述观察。在皮肤和大细胞转化的LN-MF中也发现了相似的结果。还检查了其他T细胞淋巴瘤（共7例）。仅肠病型T细胞淋巴瘤（1例）在肿瘤性T淋巴细胞中显示TP阳性。我们证明了在真菌性真菌病的肿瘤性T细胞中存在胸苷磷酸化酶染色。确切的机制需要进一步研究。

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