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首页> 外文期刊>Advancements in Life Sciences >Effect of camel milk lactoferrin against carbon tetrachloride induced hepatic toxicity in Sprague Dawley rats
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Effect of camel milk lactoferrin against carbon tetrachloride induced hepatic toxicity in Sprague Dawley rats

机译：骆驼奶乳铁蛋白对四氯化碳诱导的Sprague Dawley大鼠肝毒性的影响

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Background: Chronic Hepatitis and mortality due to liver cirrhosis is common in Pakistan. Camel milk Lactoferrin has antiviral, anti-inflammatory properties. Nutraceutical foods like camel milk have many uses. Camel milk lactoferrin might be used for the cure of hepatic fibrosis induced by CCI SUB4 /SUBin Sprague Dawley rats. Methods: Seventy-five (75) male Sprague–Dawley rats were purchased from National Institute of Health Islamabad kept in animal house of UVAS Lahore and randomly divided into 5 groups under completely randomize design. In Each group carbon tetrachloride (CC1SUB4/SUB) was subcutaneously injected with a mixture of 40% CCI SUB4 /SUB(a mixture of pure CC1SUB4/SUB and sterile olive oil) at 200 uL/100g body weight as single dose, 48 hrs before the starting of treatment or 0 day. After 48 hrs. Rats were considered hepatic injured except the (+ve) control group. Among all groups, four groups –ve control, 30mg/kg/b.wt, 60mg/kg/b.wt and 90mg/kg/b.wt were supplied with standard diet plus Lactoferrin (different concentrations and doses) orally, while control group were provided only standard diet throughout the efficacy study (30 days). Results: The study was conducted in two phases, first one was on the isolation and purification of camel milk lactoferrin and the second one was based on efficacy study of lactoferrin in Sprague Dawley rats against the hepatic toxicity induced by carbon tetrachloride Conclusion: The present study on CCl4 induced hepatotoxicity in Sprague Dawley rats clarifies that camel milk lactoferrin induced significant improvement in serum level of ALP, AST, AST, bilirubin, serum urea and serum Creatinine within the duration of 4 weeks treatment.
机译：背景：慢性肝炎和肝硬化导致的死亡在巴基斯坦很常见。骆驼奶乳铁蛋白具有抗病毒，抗炎特性。骆驼奶等营养食品有很多用途。骆驼奶乳铁蛋白可用于治疗CCI 4 引起的Sprague Dawley大鼠肝纤维化。方法：七十五（75）只雄性Sprague–Dawley大鼠是从国立卫生研究院伊斯兰堡购买的，该研究所藏在UVAS Lahore的动物房中，并根据完全随机设计随机分为5组。在每组中，四氯化碳（CC1 4 ）皮下注射40％CCI 4 （纯CC1 4 和无菌）的混合物。橄榄油），剂量为200 uL / 100g（单剂），开始治疗前48小时或0天。 48小时后。除（+ ve）对照组外，将大鼠视为肝损伤。在所有组中，分为四组– ve对照，分别口服30mg / kg / b.wt，60mg / kg / b.wt和90mg / kg / b.wt的标准饮食加乳铁蛋白（不同的浓度和剂量），而对照组在整个疗效研究中（30天），仅向标准组提供标准饮食。结果：该研究分两个阶段进行，第一个阶段是骆驼奶乳铁蛋白的分离和纯化，第二个阶段是基于乳铁蛋白对Sprague Dawley大鼠对抗四氯化碳所致肝毒性的功效研究。结论：本研究CCl4对Sprague Dawley大鼠肝毒性的影响表明，骆驼奶乳铁蛋白在治疗4周内可显着改善ALP，AST，AST，胆红素，血清尿素和血清肌酐的血清水平。

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