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Update on the proteomics of male infertility: A systematic review

机译：男性不育蛋白质组学的最新进展：系统评价

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Objective To assess the role of differentially expressed proteins as a resource for potential biomarker identification of infertility, as male infertility is of rising concern in reproductive medicine and evidence pertaining to its aetiology at a molecular level particularly proteomic as spermatozoa lack transcription and translation. Proteomics is considered as a major field in molecular biology to validate the target proteins in a pathophysiological state. Differential expression analysis of sperm proteins in infertile men and bioinformatics analysis offer information about their involvement in biological pathways. Materials and methods Literature search was performed on PubMed, Medline, and Science Direct databases using the keywords ‘sperm proteomics’ and ‘male infertility’. We also reviewed the relevant cross references of retrieved articles and included them in the review process. Articles written in any language other than English were excluded. Results Of 575 articles identified, preliminary screening for relevant studies eliminated 293 articles. At the next level of selection, from 282 studies only 80 articles related to male infertility condition met the selection criteria and were included in this review. Conclusion In this molecular era, sperm proteomics has created a platform for enhanced understanding of male reproductive physiology as a potential tool for identification of novel protein biomarkers related to sperm function in infertile men. Therefore, it is believed that proteomic biomarkers can overcome the gaps in information from conventional semen analysis that are of limited clinical utility.
机译：目的评估差异表达蛋白作为潜在的不育症生物标志物鉴定资源的作用，因为男性不育症在生殖医学中受到越来越多的关注，并且有关其病因的分子水平特别是蛋白质组学方面的证据，因为精子缺乏转录和翻译。蛋白质组学被认为是分子生物学的主要领域，可以验证处于病理生理状态的靶蛋白。不育男性精子蛋白的差异表达分析和生物信息学分析提供了有关其参与生物途径的信息。资料和方法使用关键词“精子蛋白质组学”和“男性不育”在PubMed，Medline和Science Direct数据库上进行文献检索。我们还审查了检索到的文章的相关交叉引用，并将其包括在审查过程中。以英语以外的其他语言撰写的文章不包括在内。结果在确定的575篇文章中，对相关研究进行的初步筛选消除了293篇文章。在282个研究的下一选择级别中，只有80篇与男性不育状况相关的文章符合选择标准，并被纳入本评价。结论在这个分子时代，精子蛋白质组学为增强对男性生殖生理的理解创造了一个平台，作为鉴定与不育男性精子功能相关的新型蛋白质生物标志物的潜在工具。因此，据信蛋白质组生物标志物可以克服来自常规精液分析的信息上的空白，这些空白在临床上用途有限。

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