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首页> 外文期刊>Artificial cells, nanomedicine, and biotechnology. >Dye-attached magnetic poly(hydroxyethyl methacrylate) nanospheres for albumin depletion from human plasma
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Dye-attached magnetic poly(hydroxyethyl methacrylate) nanospheres for albumin depletion from human plasma

机译：染料附着的磁性聚（甲基丙烯酸羟乙酯）纳米球，用于消除人血浆中的白蛋白

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The selective binding of albumin on dye-affinity nanospheres was combined with magnetic properties as an alternative approach for albumin depletion from human plasma. Magnetic poly(hydroxyethyl methacrylate) (mPHEMA) nanospheres were synthesized using mini-emulsion polymerization method in the presence of magnetite powder. The specific surface area of the mPHEMA nanospheres was found to be 1302 m2/g. Subsequent to Cibacron Blue F3GA (CB) immobilization onto mPHEMA nanospheres, a serial characterization processing was implemented. The quantity of immobilized CB was calculated as 800 μmol/g. Ultimately, albumin adsorption performance of the CB-attached mPHEMA nanospheres from both aqueous dissolving medium and human plasma were explored.
机译：白蛋白在染料亲和纳米球上的选择性结合与磁性相结合，作为从人血浆中消耗白蛋白的替代方法。在磁铁矿粉存在下，采用微乳液聚合法合成了磁性聚甲基丙烯酸羟乙酯（mPHEMA）纳米球。发现mPHEMA纳米球的比表面积为1302m2 / g。在将Cibacron Blue F3GA（CB）固定在mPHEMA纳米球上之后，进行了一系列表征处理。固定的CB的量计算为800μmol/ g。最终，研究了从水溶性介质和人血浆中吸附CB的mPHEMA纳米球的白蛋白吸附性能。

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