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Different multiple regeneration capacities of motor and sensory axons in peripheral nerve

机译：周围神经运动轴突和感觉轴突的不同多重再生能力

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After peripheral nerve injury, axons often project sprouts from the node of Ranvier proximal to the damage site. It is well known that one parent axon can sprout and maintain several regenerating axons. If enough endoneurial tubes in the distal stump are present for the regenerating axons to grow along, then the number of mature myelinated nerve fibers in the distal stump will be greater than the number in the proximal stump. “Multiple regeneration” is used to describe this phenomenon in the peripheral nerve. According to previous studies, a prominent nerve containing many axons can be repaired by the multiple regenerating axons sprouting from another nerve that contains fewer axons. Most peripheral nerves contain a mixture of myelinated motor and sensory axons as well as unmyelinated sensory and autonomic axons. In this study, a multiple regeneration animal model was developed by bridging the proximal common peroneal nerve with the distal common peroneal nerve and the tibial nerve. Differences in the multiple regeneration ratio of motor and sensory nerves were evaluated using histomorphometry one month after ablating the dorsal root ganglion (DRGs) and ventral roots, respectively. The results suggest that the motor nerves have a significantly larger multiple regeneration ratio than the sensory nerves at two different time points.
机译：周围神经损伤后，轴突经常从Ranvier结点附近的受损部位投射出新芽。众所周知，一个亲本轴突可以发芽并维持几个再生轴突。如果远端残端中存在足够的神经内膜管，以使再生轴突沿其生长，则远端残端中成熟的有髓神经纤维的数量将大于远端残端中的数量。 “多次再生”用于描述周围神经中的这种现象。根据以前的研究，可以通过从包含较少轴突的另一条神经中发芽的多个再生轴突来修复包含许多轴突的突出神经。大多数周围神经含有髓鞘运动轴突和感觉轴突的混合物，以及未髓鞘感觉轴突和自主神经轴突的混合物。在这项研究中，通过将近端腓总神经与远端腓总神经和胫骨神经桥接，建立了多再生动物模型。分别消融背根神经节（DRGs）和腹根后1个月，用组织形态测定法评估运动神经和感觉神经的多次再生比的差异。结果表明，在两个不同的时间点，运动神经比感觉神经具有更大的多重再生比。

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