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首页> 外文期刊>Artificial cells, blood substitutes, and immobilization biotechnology. >Development of Transmucosal Patch Using Nanofibers
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Development of Transmucosal Patch Using Nanofibers

机译：纳米纤维经粘膜贴剂的开发

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In the present work we have attempted to develop a novel transmucosal patch of diclofenac sodium using electrospun polycaprolactone (PCL) nanofibers. PCL nanofibers were prepared by electrospinning techniques using different polymer concentrations. Nanofibers formulations were characterized by SEM, FTIR, drug loading, and in-vitro release study using Franz diffusion cell. Studies revealed the nanofibers fabricated from 13% PCL were fracture-free, non-beaded, and ultrafine with 120 nm diameter. Release studies demonstrated the sustained release behavior of PCL nanofibers. Nanofibers can be exploited for transmucosal drug delivery of NSAID with improved therapeutic efficacy.
机译：在目前的工作中，我们尝试使用电纺聚己内酯（PCL）纳米纤维开发双氯芬酸钠的新型透粘膜贴剂。通过使用不同聚合物浓度的静电纺丝技术制备PCL纳米纤维。通过SEM，FTIR，载药量和使用Franz扩散池的体外释放研究对纳米纤维配方进行了表征。研究表明，由13％PCL制成的纳米纤维无断裂，无珠子且直径120 nm超细。释放研究表明PCL纳米纤维的持续释放行为。纳米纤维可用于NSAID的经粘膜药物递送，具有改善的治疗功效。

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