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首页> 外文期刊>Annals of Indian Academy of Neurology >Simultaneous Occurrence of Axonal Guillain–Barré Syndrome in Two Siblings Following Dengue Infection
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Simultaneous Occurrence of Axonal Guillain–Barré Syndrome in Two Siblings Following Dengue Infection

机译：登革热感染后两个兄弟姐妹同时发生轴索性格林-巴雷综合征

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Guillain–Barré syndrome (GBS) is an infrequent neurological complication of dengue viral infection. It is broadly divided into either acute inflammatory demyelinating variety or an axonal variety (acute motor axonal and acute sensory and motor axonal variants). Axonal variants are distinctly infrequent. Two brothers (18 years and 15 years) were hospitalized on the same day with complaints of acute symmetric upper- and lower-limb weakness of 7 days' duration. They did not have overt manifestations of dengue fever which preceded the neurological presentation. They had flaccid areflexic pure motor quadriparesis. Dengue IgM serology was positive in both. Nerve conduction study showed predominant axonopathic changes in both the patients. Both the patients showed significant improvement with conservative treatment during hospital stay of 7 days. This is unusual report of dengue-associated axonal GBS in two brothers. Whether simultaneous occurrence of GBS in two siblings is a coincidence or genetically determined is still a question.
机译：格林-巴利综合征（GBS）是登革热病毒感染的罕见神经系统并发症。它大致分为急性炎症性脱髓鞘变种或轴突变种（急性运动轴突以及急性感觉和运动轴突变体）。轴突变体很少见。同一天，有两个兄弟（分别为18岁和15岁）住院，主诉上肢和下肢急性对称性持续7天。在神经系统出现之前，他们没有明显的登革热表现。他们患有松弛性无反射性纯运动四眼瘫。登革热IgM血清学均为阳性。神经传导研究显示两名患者的主要轴索性改变。两名患者在住院7天期间均通过保守治疗表现出明显改善。这是两个兄弟中与登革热相关的轴突性GBS的不寻常报道。在两个兄弟姐妹中同时发生GBS是巧合还是遗传决定仍是一个问题。

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