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首页> 外文期刊>Annals of laboratory medicine. >Estrogen receptor 1, Glutathione S-transferase P1, Glutathione S-transferase M1, and Glutathione S-transferase T1 Genes with Dysmenorrhea in Korean Female Adolescents
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Estrogen receptor 1, Glutathione S-transferase P1, Glutathione S-transferase M1, and Glutathione S-transferase T1 Genes with Dysmenorrhea in Korean Female Adolescents

机译：韩国女性青少年痛经的雌激素受体1，谷胱甘肽S-转移酶P1，谷胱甘肽S-转移酶M1和谷胱甘肽S-转移酶T1基因

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Background : Dysmenorrhea is the most common gynecologic complaint among adolescent females. We investigated the association between genetic polymorphisms and dysmenorrhea. Methods : A total of 202 postmenarcheal Korean female adolescents 16-17 yr old participated in this study. Genotyping for glutathione S-transferase mu 1 (GSTM1), glutathione S-transferase theta 1 (GSTT1), glutathione S-transferase pi 1 (GSTP1), and estrogen receptor 1 (ESR1) was performed using PCR-based methods. Results : The PP+Pp genotype of the ESR1 gene was more frequent than pp genotypes in subjects with dysmenorrhea than in subjects without dysmenorrhea (odds ratio=2.440; 95% confidence interval, 1.036-5.753; P=0.040) using an unadjusted univariate logistic regression analysis. The relationship between dysmenorrhea and ESR1 gene polymorphisms remained significant after adjustment for premenstrual syndrome, years elapsed after menarche, and family history of dysmenorrhea. No significant difference was observed between subjects with dysmenorrhea and subjects without dysmenorrhea for polymorphisms of GSTM1, GSTT1, and GSTP1 genes. Conclusions : Our results suggest that ESR1 gene polymorphisms may be associated with dysmenorrhea.
机译：背景：痛经是青春期女性中最常见的妇科疾病。我们调查了遗传多态性与痛经之间的关联。方法：共有202名16-17岁的韩国初潮后女性青少年参加了这项研究。使用基于PCR的方法对谷胱甘肽S-转移酶mu 1（GSTM1），谷胱甘肽S-转移酶theta 1（GSTT1），谷胱甘肽S-转移酶pi 1（GSTP1）和雌激素受体1（ESR1）进行基因分型。结果：使用未经调整的单因素对数，ESR1基因的PP + Pp基因型在痛经患者中比在痛经患者中的pp基因型更为频繁（几率= 2.440; 95％置信区间，1.036-5.753; P = 0.040）。回归分析。调整经前期综合征，初潮后的年龄和痛经家族史后，痛经与ESR1基因多态性之间的关系仍然很明显。 GSTM1，GSTT1和GSTP1基因多态性在痛经患者和无痛经患者之间没有发现显着差异。结论：我们的结果表明ESR1基因多态性可能与痛经有关。

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