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首页> 外文期刊>Autism & Developmental Language Impairments >Early expressive and receptive language trajectories in high-risk infant siblings of children with autism spectrum disorder:
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Early expressive and receptive language trajectories in high-risk infant siblings of children with autism spectrum disorder:

机译:自闭症谱系障碍儿童的高危婴儿同胞的早期表达和接受语言轨迹:

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Background & aimsIn response to limited research on early language development in infants at high risk for Autism Spectrum Disorder (ASD), the current prospective study examined early expressive and receptive language trajectories in familial high-risk (HR) infants who were and were not later diagnosed with ASD (HR-ASD and HR-N, respectively), and low-risk (LR) controls with no family history of ASD.MethodsParticipants were 523 children (371 HR siblings, 56% boys; 152 LR controls, 52% boys) followed from age 6 or 12 months to 36 months. Based on independent, best-estimate clinical diagnoses at 36 months, HR participants were classified as HR-ASD (n?=?94; 69% boys), or HR-N (n?=?277; 52% boys); the sample also included 152 LR controls (52% boys). Expressive and receptive language trajectories were examined based on corresponding domain standard scores on the Mullen Scales of Early Learning (MSEL) at 6, 12, 24, and 36 months. In the combined sample of HR and LR infants, semi-parametric group-based modeling ...
机译:背景与目的为了回应对自闭症谱系障碍(ASD)高风险婴儿早期语言发展的有限研究,当前的前瞻性研究研究了过去和之后都不存在的家族性高危(HR)婴儿的早期表达和接受语言轨迹被诊断患有ASD(分别为HR-ASD和HR-N)和无ASD家族史的低危(LR)对照组方法参与者为523名儿童(371 HR兄弟姐妹,男孩56%; 152 LR对照,男孩52%) )的年龄从6或12个月到36个月不等。根据对36个月的独立,最佳估计的临床诊断,HR参与者被分类为HR-ASD(n?=?94; 69%男孩)或HR-N(n?=?277; 52%男孩);样本还包括152个LR对照(52%的男孩)。根据在6、12、24和36个月时的Mullen早期学习量表(MSEL)上相应的领域标准评分,检查了表达和接受语言的轨迹。在HR和LR婴儿的组合样本中,基于半参数分组的建模...

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